Acute behavioral and physiological effects of modafinil in drug abusers.
Rush CR, Kelly TH, Hays LR, Baker RW, Wooten AF.
Department of Behavioral Science,
University of Kentucky,
Lexington, Kentucky 40536-0086, USA. crush2@uky.edu
Behav Pharmacol 2002 Mar;13(2):105-15
Abstract
Modafinil, a novel stimulant, is effective in the treatment of excessive daytime sleepiness associated with narcolepsy.
It is biochemically and pharmacologically distinct from prototypical stimulants such as D-amphetamine, cocaine, and methylphenidate. The present experiment was designed to assess the acute behavioral effects of oral
modafinil, cocaine, and placebo in participants (n=9) with recent histories of cocaine use (i.e. positive urine for cocaine or benzoylecgonine during the initial screening interview).
Drug effects were assessed with a battery of self-reported drug-effect questionnaires, performance measures, and physiological indices. Cocaine, but not
modafinil, produced stimulant-like self-reported drug effects (e.g. increased ratings of High and Stimulated).
Modafinil and cocaine dose-dependently increased heart rate and blood pressure. The results of the present study suggest that
modafinil has minimal abuse potential, but should be viewed cautiously because of the relatively small sample size.
Future studies should further characterize the abuse potential of modafinil
using other behavioral arrangements, such as drug discrimination or drug self-administration.
A full characterization of the abuse potential of modafinil
will become important as the use of this drug increases.
1. Modafinil for
sustaining the alertness of helicopter pilots
2. Modafinil augmentation
of antidepressant treatment
3. Modafinil the
unique properties of a new stimulant
4. Modafinil children
with attention-deficit/hyperactivity disorder
5. Modafinil dosage
and safety
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil narcolepsy:
symptoms and management
8. Modafinil
amplification of cortical serotonin release
9. Modafinil
treatment of alcoholic organic brain syndrome
10. Modafinil
effect on melatonin, cortisol, and growth hormone
11. Modafinil
in obstructive sleep apnea-hypopnea syndrome
12. Modafinil
vs dextroamphetamine in treatment of adult ADHD
13. Modafinil
efficacy in narcolepsy
14. Modafinil
switching from narcolepsy drugs to modafinil
15. Modafinil
dopaminergic transmission mediates CNS stimulants
