Modafinil in children with
attention-deficit hyperactivity disorder.
Rugino TA, Samsock TC.
Department of Pediatrics
Joan C. Edwards School of Medicine
Marshall University, Huntington, WV USA
Pediatr Neurol. 2003 Aug; 29(2): 136-42.
Abstract
Previous clinical evidence suggested that
modafinil may improve clinical features of children with attention-deficit
hyperactivity disorder. To test this hypothesis, a randomized, double-blind,
placebo-controlled study design was used. Of 24 children initially randomized
into the study, 11 control subjects and 11 treatment patients completed the
study, with evaluation before medication and after 5 to 6 weeks. The average
Test of Variables of Attention attention-deficit hyperactivity disorder z
score improved by 2.53 S.D.s for the modafinil group compared with a decline
of 1.02 for control patients (P < or = 0.02). Conners Rating Scales ADHD total
t scores for the modafinil group improved from 76.6 to 68.2 compared with
improvement from 77.7 to 76.0 for control subjects (P = 0.04). Ten of 11
treatment patients were reported as "significantly" improved, whereas eight of
11 control subjects were reported as manifesting "no" or "slight" improvement
(P < 0.001). Adverse effects were few and manageable, with no anorexia.
Modafinil may be a useful treatment for children with ADHD, particularly when
anorexia limits use of stimulants.
1. Modafinil for
sustaining the alertness of helicopter pilots
2. Modafinil augmentation
of antidepressant treatment
3. Modafinil the
unique properties of a new stimulant
4. Modafinil children
with attention-deficit/hyperactivity disorder
5. Modafinil dosage
and safety
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil narcolepsy:
symptoms and management
8. Modafinil
amplification of cortical serotonin release
9. Modafinil
treatment of alcoholic organic brain syndrome
10. Modafinil
effect on melatonin, cortisol, and growth hormone
11. Modafinil
in obstructive sleep apnea-hypopnea syndrome
12. Modafinil
vs dextroamphetamine in treatment of adult ADHD
13. Modafinil
efficacy in narcolepsy
14. Modafinil
switching from narcolepsy drugs to modafinil
15. Modafinil
dopaminergic transmission mediates CNS stimulants
