Modafinil in obstructive sleep apnea-hypopnea
syndrome: a pilot study in 6 patients

Arnulf I, Homeyer P, Garma L, Whitelaw WA, Derenne JP

Service de Pneumologie et Laboratoire du Sommeil,
Hopital Pitie-Salpetriere, Paris, France.
Respiration 1997; 64(2):159-61

ABSTRACT

We studied the effects of modafinil, a vigilance-enhancing drug, on excessive daytime sleepiness, memory, night sleep and respiration in 6 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) using a double-blind random cross-over design with 24-hour polysomnography, verbal memory test and a 5-week sleep-wake diary kept by the patients. There were two 2-week treatment periods in which either modafinil or placebo was used; they were separated by a 1-week wash-out period. Our results show that modafinil reduces daytime sleep duration, lengthens the duration of subjective daytime vigilance and improves long-term memory in patients with OSAHS without modifying night sleep and respiration events.

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 2.   Modafinil  augmentation of antidepressant treatment
 3.   Modafinil  the unique properties of a new stimulant 
 4.   Modafinil  children with attention-deficit/hyperactivity disorder
 5.   Modafinil  dosage and safety
 6.   Modafinil  successful treatment of hypersomnia & narcolepsy
 7.   Modafinil  narcolepsy: symptoms and management
 8.   Modafinil  amplification of cortical serotonin release
 9.   Modafinil  treatment of alcoholic organic brain syndrome
10.  Modafinil  effect on melatonin, cortisol, and growth hormone
11.  Modafinil  in obstructive sleep apnea-hypopnea syndrome
12.  Modafinil  vs dextroamphetamine in treatment of adult ADHD
13.  Modafinil  efficacy in narcolepsy
14.  Modafinil  switching from other narcolepsy to modafinil
15.  Modafinil  dopaminergic transmission mediates CNS stimulants

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