A prospective trial of
modafinil as an adjunctive treatment of major depression.
DeBattista C, Lembke A,
Solvason HB, Ghebremichael R, Poirier J.
J Clin Psychopharmacol. 2004 Feb; 24(1): 87-90
Abstract
SUMMARY: Modafinil is a wake-promoting agent
approved by the Federal Drug Administration for the treatment of narcolepsy.
Preliminary evidence indicates that modafinil may improve fatigue and excessive
sleepiness associated with a variety of conditions. The purpose of this study
was to investigate the utility of modafinil as an adjunctive treatment of
depressed patients. Subjects with a history of major depression with partial
response on a stable therapeutic dose of an antidepressant were eligible to
participate. All subjects endorsed complaints of significant fatigue and/or
excessive sleepiness on clinical assessment. Modafinil was added to their
existing regimen at a dose of 100 to 400 mg/d for 4 weeks. Subjects were
assessed at 2-week intervals for improvement using the standard depression
scales (HDRS, BDI, CGI), fatigue scales (VASF, FSI), and a neuropsychologic
battery. Thirty-five subjects were entered and 31 subjects completed the 4-week
trial. Significant improvements were seen across all 3 measures of depression
(HDRS, BDI, CGIS) and both measures of fatigue (VASF, FSI). On the
neurocognitive battery, significant gains in the Stroop Interference Test were
seen at 4 weeks, whereas the other cognitive tests showed no change.
Modafinil may be a useful and a well-tolerated adjunctive agent to standard
antidepressants in the treatment of major depression.
1. Modafinil for
sustaining the alertness of helicopter pilots
2. Modafinil augmentation
of antidepressant treatment
3. Modafinil the
unique properties of a new stimulant
4. Modafinil children
with attention-deficit/hyperactivity disorder
5. Modafinil dosage
and safety
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil narcolepsy:
symptoms and management
8. Modafinil
amplification of cortical serotonin release
9. Modafinil
treatment of alcoholic organic brain syndrome
10. Modafinil
effect on melatonin, cortisol, and growth hormone
11. Modafinil
in obstructive sleep apnea-hypopnea syndrome
12. Modafinil
vs dextroamphetamine in treatment of adult ADHD
13. Modafinil
efficacy in narcolepsy
14. Modafinil
switching from narcolepsy drugs to modafinil
15. Modafinil
dopaminergic transmission mediates CNS stimulants
