Modafinil in diurnal sleepiness.
A study of 123 patients.
Laffont F, Mayer G, Minz M.
Unite de Sommeil,
Explorations Fonctionnelles Neurologiques,
CHU Pitie-Salpetriere, Paris, France.
Sleep 1994 Dec;17(8 Suppl):S113-5
ABSTRACT
The efficacy of modafinil, a psychostimulant drug acting on
postsynaptic alpha-1 adrenergic receptors, as a treatment for excessive
daytime sleepiness was studied in 123 patients. Subjects included 94
narcoleptic patients (76 with cataplexy), 23 hypersomnia patients and 6
patients with disrupted nocturnal sleep (DNS) and excessive daytime sleepiness
(EDS). Clinical efficacy of the treatment on each symptom (EDS, cataplexy and
DNS) was evaluated on a four-point scale from excellent to absent. The
effectiveness of modafinil as a treatment for EDS was excellent in 17% of all
patients, good in 63%, fair in 17% and absent in 3%. The incidence of side
effects was rather low (14 of 123 patients) and most of them disappeared (11
patients) when doses were reduced.
1. Modafinil for
sustaining the alertness of helicopter pilots
2. Modafinil augmentation
of antidepressant treatment
3. Modafinil the
unique properties of a new stimulant
4. Modafinil children
with attention-deficit/hyperactivity disorder
5. Modafinil dosage
and safety
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil narcolepsy:
symptoms and management
8. Modafinil
amplification of cortical serotonin release
9. Modafinil
treatment of alcoholic organic brain syndrome
10. Modafinil
effect on melatonin, cortisol, and growth hormone
11. Modafinil
in obstructive sleep apnea-hypopnea syndrome
12. Modafinil
vs dextroamphetamine in treatment of adult ADHD
13. Modafinil
efficacy in narcolepsy
14. Modafinil
switching from narcolepsy drugs to modafinil
15. Modafinil
dopaminergic transmission mediates CNS stimulants
