Nonamphetamine
awakening agent modafinil
induces feeding changes in the rat.
Nicolaidis S, De Saint Hilaire Z.
CNRS UA 637, INSERM,
Neurobiologie des Regulations,
College de France, Paris, France
Brain Res Bull 1993;32(2):87-90
Abstract:
In rats, modafinil, an alpha1 adrenergic receptor dependent,
that has been shown to increase wakefulness without subsequent rebound effect,
decreases feeding and reduces body weight. However, modafinil does not show a
monotonic dose-related decrease in food intake. The dose-response curve for
modafinil is U-shaped; feeding decreases after doses of 20 and 40 mg/kg, but no
effects were seen after doses of 10 and 80 mg/kg. When feeding is resumed, no
compensatory effect is seen, and body weight remains lower during the 24-h
session. The drinking-to-feeding ratio remains unchanged, showing that modafinil
has no effect on water intake. These results are discussed with reference to the
possible mechanisms underlying the relation between sleep, feeding, and
metabolism.
1. Modafinil for sustaining
the alertness of helicopter pilots
2. Modafinil augmentation
of antidepressant treatment
3. Modafinil the
unique properties of a new stimulant
4. Modafinil children
with attention-deficit/hyperactivity disorder
5. Modafinil tolerability
in healthy male volunteers
6. Modafinil successful treatment of
hypersomnia & narcolepsy
7. Modafinil narcolepsy:
symptoms and management
8. Modafinil
amplification of cortical serotonin release
9. Modafinil
treatment of alcoholic organic brain syndrome
10. Modafinil
effect on melatonin, cortisol, and growth hormone
11. Modafinil
in obstructive sleep apnea-hypopnea syndrome
