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Effect of modafinil on plasma
melatonin, cortisol and growth hormone rhythms, rectal temperature and
performance in healthy subjects during a 36 h sleep deprivation.
Brun J; Chamba G; Khalfallah Y; Girard P;
Boissy I; Bastuji H;
Sassolas G; Claustrat B
Service de Radiopharmacie et Radioanalyse,
Centre de
Medecine Nucleaire,
Hopital NeuroCardiologique, Lyon, France.
J Sleep Res - 1998 Jun; 7(2): 105-14
Abstract
Modafinil is an alerting substance which has been used successfully
to treat narcolepsy. Nothing is known about its effect on hormone
secretions. For this purpose, eight healthy young men were enrolled in
a double blind trial to test the effects of modafinil on daily plasma
melatonin, cortisol and growth hormone (GH) rhythms. Blood was sampled for
hormone assays, every hour during the daytime and every 30 min during the
nighttime. In addition, rectal temperature and mental performances were
determined during the study which comprised 3 sessions, two weeks apart: a
24 h control session including a night with sleep (S1) and two 48 h sessions
S2 and S3 with a sleep-deprived night (N1) followed by a recovery night
(N2). Modafinil (300 mg x 2) or placebo were randomly attributed during N1
at 22 h and 8 h. As expected, performance was improved after modafinil
administration and body temperature was maintained or increased.
Plasma melatonin and cortisol profiles were similar after modafinil
and
placebo administration. The levels observed during the recovery and the
control nights (N2) displayed no difference. For GH, during both sleep
deprived nights, secretion was dramatically reduced compared with the
control one, although the number of secretory episodes was unchanged. These
data show that the alerting property of modafinil is not related to
an alteration of hormone profiles and suggest that the acute modafinil
administration is devoid of short-term side-effects.
1. modafinil is
a potential treatment for fibromyalgia
2. modafinil improves
fatigue in patients with multiple sclerosis
3. modafinil offers
promise as an augmentation to antidepressants
4. modafinil excessive
sleepiness in Parkinson's disease
5. modafinil excessive
daytime sleepiness in Parkinson's disease
6. modafinil may
be useful for attention-deficit/hyperactivity disorder
7. modafinil benefits
cerebral palsy in an unknown way
8. modafinil
article
9. modafinil
amplification of cortical serotonin release
10. modafinil
treatment of alcoholic organic brain syndrome
11. modafinil
effect on melatonin, cortisol, and growth hormone
12. modafinil
in obstructive sleep apnea-hypopnea syndrome
13. modafinil
vs dextroamphetamine in treatment of adult ADHD
14. modafinil
efficacy in narcolepsy
15. modafinil
switching from narcolepsy drugs to modafinil
16. modafinil
drug of choice for narcolepsy
17. modafinil
dopaminergic transmission mediates CNS stimulants
18. modafinil
for daytime sleepiness in sleep apnea
19. modafinil
treatment of residual excessive daytime sleepiness
20. modafinil
in the treatment of narcolepsy
21. modafinil
and naps as counter measures in sleep
deprivation
22. modafinil
effect on narcolepsy
23. modafinil
as a treatment for excessive daytime sleepiness
24. modafinil
a narcolepsy study
25. modafinil
use in a sleep deprivation experiment
26. modafinil for
sustaining the alertness of helicopter pilots
27. modafinil the
unique properties of a new stimulant
28. modafinil dosage
and safety
29. modafinil in
treatment of fatigue in multiple sclerosis
30. modafinil non-addictive
potential of modafinil
31. modafinil successful
treatment of hypersomnia & narcolepsy
32. modafinil physiological
effects of modafinil in drug abusers
33. modafinil narcolepsy:
symptoms and management
34. modafinil cognitive
enhancing effects of modafinil
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