Narcolepsy.
Bassetti C.
Neurology Department,
University Hospital (Inselspital),
3010 Bern, Switzerland.
Curr Treat Options Neurol
1999 Sep;1(4):291-298
ABSTRACT
Narcolepsy is a disabling, chronic
sleep-wake disorder that typically starts in a patient's second or third
decade of life. Its key features are hypersomnia and cataplexy. Sleep
paralysis, hallucinations, and disrupted sleep are nonspecific symptoms and
are not always present. Disability relates primarily to sleepiness- related
cognitive impairment, accidents, and psychosocial problems. Treatment,
which includes counseling, scheduled napping, and pharmacologic intervention,
is effective for most patients. Hypersomnia is best treated with such
indirect sympathomimetics as mazindol, pemoline, methylphenidate, and
amphetamine. Modafinil may become the drug of choice because it has
fewer side effects. Cataplexy, sleep paralysis, and hallucinations may be
ameliorated by compounds, including clomipramine and imipramine, that suppress
rapid eye movement (REM) sleep. Regular follow-up visits enable the
clinician to recognize uncommon but serious side effects (tolerance, substance
abuse, psychosis, and hypertension) and additional sleep disturbances (sleep
apnea, periodic limb movements in sleep, REM sleep behavior disorder), which
can be specifically treated.
1. modafinil is
a potential treatment for fibromyalgia
2. modafinil improves
fatigue in patients with multiple sclerosis
3. modafinil offers
promise as an augmentation to antidepressants
4. modafinil excessive
sleepiness in Parkinson's disease
5. modafinil excessive
daytime sleepiness in Parkinson's disease
6. modafinil may
be useful for attention-deficit/hyperactivity disorder
7. modafinil benefits
cerebral palsy in an unknown way
8. modafinil
article
9. modafinil
amplification of cortical serotonin release
10. modafinil
treatment of alcoholic organic brain syndrome
11. modafinil
effect on melatonin, cortisol, and growth hormone
12. modafinil
in obstructive sleep apnea-hypopnea syndrome
13. modafinil
vs dextroamphetamine in treatment of adult ADHD
14. modafinil
efficacy in narcolepsy
15. modafinil
switching from narcolepsy drugs to modafinil
16. modafinil
drug of choice for narcolepsy
17. modafinil
dopaminergic transmission mediates CNS stimulants
18. modafinil
for daytime sleepiness in sleep apnea
19. modafinil
treatment of residual excessive daytime sleepiness
20. modafinil
in the treatment of narcolepsy
21. modafinil
and naps as counter measures in sleep deprivation
22. modafinil
effect on narcolepsy
23. modafinil
as a treatment for excessive daytime sleepiness
24. modafinil
a narcolepsy study
25. modafinil
use in a sleep deprivation experiment
26. modafinil for
sustaining the alertness of helicopter pilots
27. modafinil the
unique properties of a new stimulant
28. modafinil dosage
and safety
29. modafinil in
treatment of fatigue in multiple sclerosis
30. modafinil non-addictive
potential of modafinil
31. modafinil successful
treatment of hypersomnia & narcolepsy
32. modafinil physiological
effects of modafinil in drug abusers
33. modafinil narcolepsy:
symptoms and management
34. modafinil cognitive
enhancing effects of modafinil
