Interest of modafinil, a new
psychostimulant, during a sixty-hour sleep deprivation experiment.
Lagarde D, Batejat D, Van Beers P, Sarafian D, Pradella S.
Institut de Medecine
Aerospatiale (Imassa-Cerma),
Departement Sciences Cognitives et Ergonomie,
Bretigny-sur-Orge, France.
Fundam Clin Pharmacol 1995;9(3):271-9
ABSTRACT
Modafinil, a new psychostimulant,
was evaluated in eight healthy volunteers subjected to 60 hours of sleep
deprivation. During continued wakefulness, vigilance was evaluated by
self-assessment questionnaires, analogue visual scales, multiple sleep latency
tests (MSLT), sleep logs, and continuous ambulatory electroencephalographic
recordings (EEG). Modafinil (200 mg) or a placebo was given every 8 hours for
three days; the sessions were separated by a 15 day wash out period. Results
indicated a satisfactory level of vigilance, both subjective and objective,
after the administration of modafinil, characterised by the quasi total
absence of microsleep episodes which gradually occurred under placebo
conditions. The confirmed wakening potency of modafinil
makes this substance
suitable for therapeutic use in patients with sleep disorders such as
Gelineau's syndrome and hypersomnia.
1. Modafinil for
sustaining the alertness of helicopter pilots
2. Modafinil augmentation
of antidepressant treatment
3. Modafinil the
unique properties of a new stimulant
4. Modafinil children
with attention-deficit/hyperactivity disorder
5. Modafinil dosage
and safety
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil narcolepsy:
symptoms and management
8. Modafinil
amplification of cortical serotonin release
9. Modafinil
treatment of alcoholic organic brain syndrome
10. Modafinil
effect on melatonin, cortisol, and growth hormone
11. Modafinil
in obstructive sleep apnea-hypopnea syndrome
12. Modafinil
vs dextroamphetamine in treatment of adult ADHD
13. Modafinil
efficacy in narcolepsy
14. Modafinil
switching from narcolepsy drugs to modafinil
15. Modafinil
dopaminergic transmission mediates CNS stimulants
