Adderall and modafinil are both powerful nootropic compounds. They increase energy levels, make us feel alert and awake, and can dramatically improve our productivity.
Since they both offer these effects, taking them in combination probably makes them even better! Right?
Well, not exactly.
Although both medications can be extremely useful, mixing them together requires some care and caution. Doing it properly will rely on a few different factors.
How Modafinil Works
Modafinil is considered a eugeroic medication. This means that it promotes wakefulness in the brain.
It Increases Orexin
Orexin is a special neurochemical used by the brain to promote wakefulness. It originates deep within the brain, in the hypothalamus.
It travels upward to other areas of the brain to trigger arousal and wakefulness and inhibits appetite.
Narcolepsy is a medical condition involving poor orexin production in the brain. People suffering from this condition experience excessive daytime sleepiness and will often fall into a deep sleep suddenly and with little warning.
Both modafinil & Adderall have the ability to increase orexin levels in the brain, which has made it a staple in the treatment of conditions like narcolepsy.
It Increases Dopamine
Dopamine is an important neurotransmitter. It’s associated with several important cognitive processes. It’s used in learning, memory formation & retrieval, mood, punishment, and regulation of the body’s hormone levels.
Normally, dopamine is produced in the nucleus accumbens and travels to the synapses. Here, it’s used to transmit a signal from one neuron to another.
Once used, the dopamine molecule is reabsorbed into the neuron, and broken down by enzymes in the cell.
Modafinil works to increase dopamine levels by inhibiting the reabsorption of dopamine after it’s been released in the synapses. This prevents it from being broken down in the neuron and allows it to exert its effects for a longer amount of time.
Modafinil targets a very specific dopamine transporter known as DAT. This specificity makes modafinil more efficient at inhibiting the reuptake of dopamine and lowers the chances of undesired side effects.
It Increases Norepinephrine
Norepinephrine is one of our main stimulatory neurotransmitters. It’s closely associated with our fight or flight response. It helps us feel sharp when we come face to face with a hungry tiger.
It also increases heart rate and blood pressure to ensure adequate blood flow to the muscles and the brain to help us escape a dangerous situation.
Modafinil increases norepinephrine in a similar way to dopamine, by inhibiting its reabsorption into the synapses after it’s been released. This allows it to take effect longer within the synapses of the brain. .
It Increases Histamine Release in the Brain
Most people think of allergies when they hear the word histamine.
Although this is certainly an important role histamine plays in the body, it’s far from the only thing it does.
Histamine is actually a very versatile compound.
In the brain, it’s used as a stimulant. It’s a key element of the waking process and is necessary for us to feel alert and focused. .
This is why many of our common anti-allergy, antihistamine medications cause excessive drowsiness. By inhibiting histamine, we are essentially lowering our brain’s ability to stimulate itself and feel alert and awake.
Modafinil has been shown in several studies to increase histamine (H2) release in the brain by 150% .
Buy Modafinil Online
Therefore, buying the drug without a prescription in your local pharmacy is next to impossible.
Due to a legal grey area in how modafinil is classified, it’s possible to buy the drug online without a prescription.
This works because the governments of the world only regulate those selling the drug, not those buying it. This allows sellers located outside of the jurisdiction of these countries to sell the medication online.
There are a number of online vendors in this space, however, due to the legal grey area, it remains mostly unregulated. There are a ton of poor quality vendors online selling modafinil and other prescription medications. This makes it important to do some research on any vendor before making an order with them.
Luckily, we’ve done a lot of the research for you, and have ordered modafinil from a variety of sources to see who offers the best product, for the best price.
Our favorite source for modafinil at the moment is Afinil.com.
We’ve found that the quality of modafinil supplied by afinil.com is top notch, and their customer service is some of the best in the industry.
Our package came promptly and shipping was free!
If you pay with Bitcoin or other cryptocurrencies, you can save 20% on your order.
How Adderall Works
Adderall is very similar in a lot of ways to modafinil but has some distinct differences.
It Increases Dopamine Levels
Adderall increases dopamine levels in the brain by inhibiting the reuptake of the compound through the same transporter modafinil works on (DAT).
However, adderall also increases dopamine levels by forcing the ejection of dopamine from the storage site in the synapses. It does this by forcing the dopamine transporters to go into reverse, spitting dopamine out rather than reabsorbing it back into the cell. .
This causes a surge of dopamine levels from the drug, producing feelings of euphoria, and improved focus and concentration.
Modafinil vs Adderall
Modafinil and Adderall are very similar in their effects. As a result, both of them are used for similar situations. The most common use of Adderall and modafinil are for narcoleptics and for people with ADHD.
Both drugs increase dopamine concentrations, but through slightly different mechanisms.
Modafinil is like the stopper in the bathtub. It prevents the loss of dopamine by plugging the drain. Over time, dopamine concentrations rise in the brain to produce its effects.
Adderall also blocks the drain but has the added ability of turning up the faucet too.
This leads to a rise in dopamine levels much faster.
This also means that Adderall depletes dopamine stores much quicker and more severely than modafinil.
Both modafinil and Adderall have side effects.
Headaches, dehydration, low appetite, and insomnia are common side effects to both medications.
Adderall is much less specific in its effects, meaning that it can influence many different areas of the brain, including both the intended areas and unintended ones.
As a result, it tends to have a lot more side effects than modafinil.
Why Mix Modafinil & Adderall
Some people choose to combine their modafinil with Adderall. The idea is that by mixing two compounds that have similar effects, but work through different mechanisms, we can provide more reliable results.
Is It Safe?
It’s unclear whether the combination of modafinil and Adderall is safe.
Based on the way these medications work, as outlined above, it’s likely that combining the two will only serve to increase side effects or cause serious overstimulation which could reduce productivity and negate the entire reason someone would want to take these medications.
Going back to the shower example, mixing Adderall and modafinil would be like plugging the shower drain, and cranking the faucet on as high as it will go. The tub will quickly fill up with water and may start to overflow over the sides.
This is the same thing that would happen to the brain when you take these two stimulants together. Too much dopamine can cause short-term cognitive problems like headaches, anxiety, twitchiness, and irritability. Long-term effects can include insomnia, depression, low libido, and lack of motivation.
Should I Mix Adderall with My Modafinil?
Most people participating in the discussion about whether or not modafinil and Adderall SHOULD be mixed agree that they’re probably best kept apart.
We tend to agree with them.
Both of these drugs are very powerful, and there are no studies investigating the combined use of them at the same time.
The combination could be the ride of your life, but it could also lead to serious side effects.
In fact, we recommend taking only one stimulant at a time and don’t even recommend taking caffeine with your modafinil.
Modafinil works perfectly fine on its own and so does Adderall. Therefore, we see no need to mix the two together, and it serves no reasonable benefit to do so.
You can order modafinil online, with or without a prescription from Afinil.com.
If you’re looking for something stronger than your run of the mill modafinil, try their armodafinil. These are a specialized isomer of modafinil with stronger effects. Afinil.com sells this in the form of Waklert and Artvigil.
Common Side Effects of Mixing Modafinil & Adderall
- Heart palpitations
How To Mix Them Together Safely
Let’s say that despite all of the information above and you still want to mix Adderall and modafinil together, how can you do it safely?
Due to the similarities in their effects, we recommend taking them each in smaller doses if you’re going to take them at the same time.
The normal dose of modafinil is 200mg per day. The equivalent to this in Adderall is about 60mg.
Therefore, if you’re going to mix the two, start with a half dose of each. 100mg of modafinil and about 30 mg of Adderall.
You can buy modafinil in the 200 mg dose from places like Afinil.com, and use the manufacturer’s crease to break the capsules in half for even 100 mg doses.
Adderall doesn’t usually come with a crease down the middle but is supplied in doses of 10mg, 30mg, or 60mg. We recommend buying either the 10mg or 30 mg doses to mix with your modafinil.
Start Low And Increase Gradually
It’s very important that you start with a lower dose when you’re just starting. This goes for any new combination of drugs or supplements.
This is done to make sure there are no serious side effects from the medication.
Start with a half dose of each and build up slowly.
Even if you don’t feel the effects as strong as you had hoped on the first day, WAIT until the next time before increasing the dose.
An easy way to create problems for yourself is to take a second dose out of impatience before the first one took effect. This is how many people overdose on illicit drugs like MDMA (which Adderall is a close relative).
Keep in mind that Adderall doesn’t reach peak concentrations for about 3 hours , while modafinil takes about 2 hours.
Although Adderall and modafinil may seem like a good pairing, it can be unsafe, and isn’t necessary since both drugs are so similar, and both drugs work just fine on their own.
If you’re really determined to mix the two together, it’s important to start with smaller doses of each before building the dose up.
- Arrang, J. M., Devaux, B., Chodkiewicz, J. P., & Schwartz, J. C. (1988). H3‐receptors control histamine release in human brain. Journal of neurochemistry, 51(1), 105-108.
- Ishizuka, T., Sakamoto, Y., Sakurai, T., & Yamatodani, A. (2003). Modafinil increases histamine release in the anterior hypothalamus of rats. Neuroscience letters, 339(2), 143-146.
- Madras, B. K., Xie, Z., Lin, Z., Jassen, A., Panas, H., Lynch, L., … & Miller, G. M. (2006). Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. Journal of Pharmacology and Experimental Therapeutics, 319(2), 561-569.
- Sherzada, A. (2012). An analysis of ADHD drugs: Ritalin and Adderall. JCCC Honors Journal, 3(1), 2.