Noopept Review in 2024: Dosage, Benefits, and Side Effects

We’re consistently searching for ways to improve by augmenting our brainpower. We may go into mindful practices such as yoga or dive into exercise & the like. Although these practices might work, we consider looking for alternatives such as using Noopept, an outstanding cognitive-augmenting supplement, or even all-natural nootropic gummies to manage stress, support concentration, sustain energy without the jitters, and ameliorate restful sleep.

Noopept is one of the most famous synthetic nootropics on the globe right now. It’s more commonly used as a general, all-purpose, daily nootropic supplement than substances such as piracetam, Adderall, or modafinil. Noopept is a remarkably exhilarating brain supplement; preliminary analysis indicates that it may offer the same advantages as piracetam at considerably lower doses. This isn’t particularly surprising, as it’s a dipeptide piracetam analog.

In this Noopept review guide, we’ll explain what this supplement is in detail. We’ll discuss its safety, benefits & mechanism of action, dosage & expected side effects, and its comparison with nootropics, i.e., Noopept vs Adderall & piracetam. We’ll also discuss where to buy it online, and at the end of the review, we’ll give our verdict on the supplement.

What Is Noopept?

Noopept, one of several nootropics created based on the structure of piracetam, was developed in 1996 by T. A. Gudasheva at the Zakusov Institute of Pharmacology, the Russian Academy of Medical Sciences. One of its metabolites, cycloprolylglycine (CPG) is heightened in the brain 1 hour after Noopept ingestion, & it’s this metabolite that’s considered to be responsible for the longer-term nootropic activities of the supplement.

CPG is an endogenous dipeptide having a wide range of psychotropic actions & putative therapeutic potential for depression. A small but increasing body of data indicates that the antidepressant-like effect of CPG is linked with neuroplastic modifications in the brain or 5-HT system modulation. Nonetheless, the mechanisms of the dipeptide action stay elusive [1].

Cycloprolylglycine is thought to heighten the levels of the brain-derived neurotrophic factor (BDNF) in the brain. Investigators consequently asserted that a nootropic based on cycloprolylglycine would have identical effects, & that is precisely what is proclaimed about Noopept.

As a supplement, it works by augmenting acetylcholine signaling in the brain. Concurrently, it promotes the production of nerve growth factor (NGF) & also BDNF in the hippocampus, thus protecting the brain against glutamate toxicity. When there is high glutamate, it overexcites the nerve cells & destroys them quickly in a mechanism called excitotoxicity. It also augments inhibitory neurotransmission in the brain.

Certainly, Noopept is an influential synthetic nootropic with cognitive enhancement & neuroprotective effects. Because of this, it continues to be used for treating various cognitive disorders, including traumatic brain injury, cerebral vascular insufficiency, attention deficit hyperactivity disorder (ADHD), & age-affiliated cognitive decline.

About Noopept Ingredients

Noopept is a brand name for n-phenylacetyl-l-prolylglycine ethyl ester; its developmental code is GVS-111. It’s available in different forms (tablets/capsules, powder, and nasal spray). All of them have the same active ingredient, but inactive components may slightly vary depending on the final product. For instance, the liquid form of the supplement contains type II water as a solvent and acetate beside the active ingredient. Nonetheless, the most paramount constituents are the AMPA & NMDA, which are glutamate receptor stimulators, & also the NGF & BDNF protein stimulators. Indeed, they are excellent in helping the brain perform better & more efficiently.

Is This Supplement Safe?

Noopept is definitely safe to take. Nonetheless, studies on its negative effects & long-term health risks stay elusive. We can’t say with confidence if this nootropic is uncontroversial to use for extended periods. No proof exists to demonstrate any long-lasting harm from its administration.

Before you start taking Noopept, read its instruction & medical contraindications to be sure it’s safe for you. Also, following the recommendation of a professional physician is paramount.

You may require a complete examination before any Noopept usage, particularly if you have a history of headaches, seizures, memory loss, or cognitive disturbances. The supplement may correspondingly have unfavorable drug interactions with other meds, although so far, there are no documented cases. Besides, Noopept is unregulated in the USA & Canada.

Key Benefits of Noopept

Several preliminary investigations examined the possible advantages of using Noopept. Most of its benefits are still tentative. Plenty of clinical studies are underway to guarantee them. Besides its known positive effect on brain activity, Noopept nootropic also has much further health usefulness such as the following.

Improves Memory & Learning

Noopept was undoubtedly created as a therapy for cognitive impairment, & it’s best regarded as a brain promoter & memory augmenter. The nootropic assists with memory formation like piracetam but with additional advantages, including improved memory consolidation & retrieval steps [2]. The product enhances learning capability & memory by functioning in all phases of processing, from initial info processing to consolidation & also extraction.

Noopept has been used successfully in Russia to treat diverse cognitive impairments, including organic brain disease, age-related neurodegeneration, stroke, & alcohol-related brain damage. According to the study, the supplement, used at a dose of 20 mg/day for 2 months, ameliorates cognitive functions in stroke patients & has a high level of safety [3].

At present, anecdotal reports from user reviews using Noopept for its cognitive effects are positive [4][5]. Some users also experience augmented sensory perception, including ameliorated vision & hearing [6].

Augments Levels of NGF & BDNF

According to an animal study, Noopept stimulates the expression of two influential cognition-affiliated chemicals: BDNF & NGF [7].

NGF is a remarkable protein vital to the growth, maintenance, & survival of nerve cells. It’s a key component in neurogenesis that enhances the implementation of neural networks within the brain, & more useful brain structure is linked with augmented performance in practically all areas of cognition. Low levels of NGF are linked with various disorders, including bipolar disorder, Alzheimer’s disease, Rett syndrome, dementia, schizophrenia, and acute coronary & metabolic syndromes [8].

BDNF has an identical function to NGF and is predominantly active in the hippocampus, cortex, & also basal forebrain, areas of the brain that are essential to memory (short- & long-term memory formation) & higher-order thinking.

Has Neuroprotective Properties

Noopept has robust neuroprotective properties, meaning it can help protect the brain from various aspects that adversely affect cognition. It’s a potent antioxidant that safeguards cells against oxidative damage from free radicals, preliminary molecules created when the body is exposed to impurities or stressors. In this regard, oxidative damage is closely linked with age-related cognitive deterioration & neurodegenerative disorders, e.g., Alzheimer’s disease.

In addition, Noopept is an efficacious anti-inflammatory agent, which may further safeguard & improve cognition with benefits such as ameliorated reasoning, short-term memory, verbal proficiency, verbal learning & memory, & executive function. It also protects & heightens neurological health by enhancing blood flow to the brain & inhibiting neurotoxicity induced by extra glutamate & calcium.

May Lessen Anxiety & Depression

Noopept is definitely efficacious for anxiety & depression therapy and is helpful in boosting mood. Since it impacts benzodiazepine receptors linked with lowering stress levels, it can heighten your mood & help you feel better overall.

According to the studies on rats, Noopept lessens “learned helplessness” – a state of demeanor closely linked with anxiety & depression [9][10]. Once again, nonetheless, it’s ambiguous if this phenomenon would translate to more complicated animals such as humans, & much more analysis is required to properly verify this.

Additionally, Noopept functions to potentially aid you in lessening oxidative stress in the brain, lowering the risk of age-related cognitive decline, and reducing fatigue & irritability.

Reduces Brain Fog

Noopept can help prevent brain fog. Your mind feels sharper & clearer after its administration because it targets the brain for memory, focus, & learning capabilities. As said earlier, it functions by stimulating the production of NGF, which then promotes new neuron growth in the hippocampus.

The supplement also promotes a heightened sense of well-being because it lessens the stress hormone cortisol, making you feel less stressed. Nonetheless, analysis of mental fog or mental stress isn’t the most exhaustive either, as it can be entirely subjective.

Doesn’t Make You Feel High

Contrary to prevalent belief, it’s paramount to mention that it doesn’t cause you to feel euphoric or high. It doesn’t augment physiological or central nervous system activity; all it accomplishes is augmented cognitive function & brain health.

Extra Benefits

One more benefit of this nootropic is that it helps an individual during the study. It impressively heightens focus & attention for many enthusiasts and neurohackers. Mental arithmetic, as well as grasping complex concepts, is more straightforward.

Additionally, Noopept augments verbal fluency. Your conversation skills might be improved after using this nootropic. Vocabulary comes easier and you become more focused, which contributes to a more balanced dialogue.

How to Use Noopept: Dosage Guide

How to take Noopept? There are several ways to do this: you can opt for sublingual, oral, or intranasal administration.

In this regard, oral Noopept involves pills or capsules. For first-time users, this is the most suitable way of administration because it’s straightforward, convenient, & safe. Some individuals prefer sublingual Noopept because it bypasses metabolic & digestive operations, which implies it isn’t broken down when it penetrates the bloodstream. As for intranasal Noopept, it has a much more robust influence on the brain because it doesn’t get digested & be metabolized.

Now, how much Noopept should you administer?

For oral form, the recommended dosage for a grown-up is 10 to 30 mg, relying on individual weight. Nonetheless, it’s advisable to start with just 10 mg to evaluate the influence on your body. Take solely the minimum amount you require for your safety. It will help you avoid building a tolerance to the med.

Start at a bit lower dose if you choose sublingual administration of Noopept, at approximately 5 mg. Observe how your body reacts to it before raising it to the typical 10 mg dose.

You may also consider megadosing Noopept to see dramatic improvements in your brain. If a standard dose is 10 to 30 mg, a nootropic megadose is a whopping 50–100 mg. Some individuals take amounts more significant than 100 mg. This should only be done once a week at most, as persistent use could make it less efficacious in the long term, & it would no longer function as a cognitive augmenter. Take note that high doses could pose dangers for some individuals. Be sure you’re fully conscious of your tolerance level before trying this.

The official package insert for Noopept states that its half-life in humans is 0.38 hours or 22.8 minutes. Anecdotally, its short duration of action (60–90 minutes) depends on individual physiology, weight, & dose ingested.

Noopept withdrawal is mild & only manifests itself when taken in extraordinarily high doses for a long period.

Side Effects & Warnings

Noopept hasn’t been well studied in terms of negative effects & long-term health risks. However, most physicians refer to it as a well-tolerated med. It has a minimal number of negative effects, & they are the following:

• irritability;
• anxiety;
• nausea;
• headache;
• lightheadedness;
• insomnia – specifically when administered at night.

There can be other possible negative effects, and most of them are easy to manage. For instance, if it induces sleeplessness, consider ingesting Noopept earlier in the day. By doing so, your brainpower will diminish by the time it is evening, & you can sleep without feeling unsettled.

Furthermore, most of the other negative effects might be induced by an overdose. Sort this out by lowering the dosage.

Here are absolute contraindications to the use of Noopept:

• kidney & liver dysfunction;
• pregnancy & lactation;
• hypersensitivity to one of the med’s components.

Besides, minors younger than 18 years of age shouldn’t take it. If you have any chronic ailments, tell your physician about your purpose to purchase Noopept.

Take note that this supplement is gentler on your liver than the famous “smart tab” modafinil. Besides, you only need to ingest 20 mg of Noopept to obtain the effects of 100 mg of modafinil. Lesser quantities imply less strain on the liver & also the kidneys. Don’t stack both modafinil & Noopept since they both are too powerful, & mixing them might lead to some serious negative effects. However, you may combine Noopept & aniracetam since they are classified as components of the racetam family. Such a mix can ameliorate mood & memory and help handle emotionally draining tasks better.

By the way, Noopept goes well with choline. It is a powerful nutrient that’s important for cellular function. It plays a major role in memory formation & also brain function. In this case, choline & Noopept supplementation offers neuroprotective benefits by augmenting brain power.

Noopept vs. Piracetam

Noopept is structurally identical to piracetam. These nootropics have similar effects, with Noopept having a better capability to heighten cognition. The latter is much more potent & is absorbed more rapidly. It just needs a much lower dose for similar cognitive effects [2]. When it comes to the half-life of Noopept vs Piracetam, the former has an extremely short half-life, but a big plus is that it has minimal undesirable psychostimulatory effects.

Noopept vs. Adderall

Both products are equally robust & might have identical effects at low doses. That said, Adderall’s negative reactions are considered to be life-threatening. Besides, Noopept is indeed the milder one of the two. In lower doses, Adderall can be a beneficial enhancement to augment brain function, but in higher doses, it can induce euphoria. Noopept doesn’t cause overexcitement or euphoria.

How to Get Noopept Online?

Noopept & its variants such as Noopept nasal spray aren’t typically available for sale at brick-and-mortar stores. If you opt to shop for it, you’ll need to order it online. You may order it from PureNootropics.net, a reliable & reputable source for genuine bulk nootropic products.

Most individuals prefer purchasing Noopept from Nootropics Depot, another reliable vendor you can bank on. Nonetheless, there are lots of online vendors to buy the desired nootropic supplement. Also, LiftMode used to sell highly pure Noopept powder, but it doesn’t offer it at the time of writing this review. The reason is the adaption to the present regulatory regime & pressures being applied to & by acquiring banks [11].

Is It Possible to Buy Nootropic on Amazon?

Certainly, it can be very difficult to find the branded Noopept on Amazon. Most of the variants aren’t available in-store at the moment. Just perform a simple search on Amazon to determine if it stocks it. Typically, this nootropic falls into the gray area between legal & illegal substances since it has not been authorized by the Food and Drug Administration (FDA), and there is no strong research backing it. And though there’s nothing illegal about it, it’s indeed not freely obtainable for unregulated use.

The Verdict: Full Noopept Review

Noopept is very good in augmenting the action of NGF & BDNF in the brain. Additionally, it boosts the efficiency of acetylcholine processes & ultimately aids in protecting the brain against glutamate toxicity. The nootropic is effective and well-tolerated. It functions well independently, and it shines in the mix with other safe nootropics, which makes it a popular choice for stacking.

Most Noopept negative effects are linked to an overdose, & the likelihood of developing tolerance is indeed easily managed through cycling. The pros of the supplement outweigh the cons, & the negative effects are nothing too serious. The last thing is to make sure you ingest the safe dose while noting how it affects your brain function. Start slow, and based on tolerability & effects, you can build it up as you go.

References

1. The neuropeptide cycloprolylglycine produces antidepressant-like effect and enhances BDNF gene expression in the mice cortex. By Aliya A. Abdullina, Ekaterina V. Vasileva, Elizabeth A. Kulikova, et al. Published: February 2022. Pubmed.ncbi.nlm.nih.gov.
2. [The original novel nootropic and neuroprotective agent noopept]. By R. U. Ostrovskaia, T. A. Gudasheva, T. A. Voronina, and S. B. Seredenin. Published: September 2002. Pubmed.ncbi.nlm.nih.gov.
3. [Noopept in the treatment of mild cognitive impairment in patients with stroke]. By A. V. Amelin, A. Iu. Iliukhina, and A. A. Shmonin. Published: 2011. Pubmed.ncbi.nlm.nih.gov.
4. Which nootropics had a significant improvement in your learning and memory? By u/enzio901. Retrieved: July 31, 2022. Reddit.com.
5. Best “one pill” nootropic? By u/ZBXY4. Retrieved: July 31, 2022. Reddit.com.
6. Noopept vision changes? Retrieved: July 31, 2022. Reddit.com.
7. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. By R. U. Ostrovskaya, T. A. Gudasheva, A. P. Zaplina, Ju. V. Vahitova, M. H. Salimgareeva, R. S. Jamidanov, and S. B. Seredenin. Published: September 2008. Pubmed.ncbi.nlm.nih.gov.
8. Nerve growth factor. Retrieved: July 1, 2022. Wikidoc.org.
9. Effect of noopept and afobazole on the development of neurosis of learned helplessness in rats. By A. A. Uyanaev, V. P. Fisenko, and N. K. Khitrov. Published: August 2003. Pubmed.ncbi.nlm.nih.gov.
10. Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis. By A. A. Uyanaev and V. P. Fisenko. Published: August 2006. Pubmed.ncbi.nlm.nih.gov.
11. Why does Liftmode stop selling noopept? By u/Curious-Entity. Retrieved: July 31, 2022. Reddit.com.