Beginners Guide to Modvigil

One of the most popular families of cognitive enhancing drugs is the Afinil family. This family includes several different versions of Modafinil, Armodafinil, and Adrafinil.

The cheapest option within this family is Modvigil, which itself is a generic version of Modafinil. It’s thought to have a milder effect compared to others in its class, which brings several benefits to those looking to use Modafinil to boost their productivity.

Here, we discuss Modvigil, how it’s used, how much to take, and how it compares to others in its class.

Find Modvigil online. 

 

What Is Modvigil?

Modvigil is a generic version of Modafinil. It’s prescribed by doctors for ADD/ADHD, narcolepsy, or shift workers managing sleep disturbances.

It’s also popular outside of this prescribed range among students, creative professionals, and business owners for its ability to increase focus and productivity. Many refer to this drug as a “study drug” for this reason.

There are several different companies that make Modafinil.

The brand name of this drug, Provigil,  is made by the American company Cephalon Inc.

Modvigil is a generic and off-brand version of Modafinil made by the Indian pharmaceutical company HAB Pharma. It’s essentially the same chemical as the brand name product but comes at a much lower price.

There are few differences in regards to quality and testing standards between generic drugs and brand name drugs. The major difference, however, is the price.

Brand name Modafinil (Provigil) can cost as much as 50 times the off-brand versions like Modvigil or Modalert.

This is the same with other industries as well, like clothing. A brand name shirt made from one company may be many times more expensive than an otherwise virtually identical shirt made by another company.

You are essentially paying for the company’s reputation.

Where To Buy Modvigil

Due to the legal status of Modvigil, it cannot be bought in stores based out of Europe, the United States, Canada, or Australia.

Modvigil can, however, be bought from online vendors selling Modafinil and Armodafinil generics based out of countries like India that don’t classify the drug as a prescription-only medication.

Our favourite vendor for Modvigil is Afinil.com.

This company is based out of India and offers sales to North America, Europe, and Australia. They offer guaranteed delivery, free shipping, and take payments in credit card, and cryptocurrencies like Bitcoin.

 

Why Do Generic Versions of Drugs Exist?

Whenever a new drug is invented, the company who invented it will secure a patent. This patent prevents other companies from manufacturing the drug for a certain period of time (usually 20 years). Once the patent term ends, other companies have the option of making their own generic versions of the drugs.

In the case of Modafinil, and Armodafinil, companies like HAB Pharma and Sun Pharma have stepped up to produce their own versions, which is where we get Modvigil and Modalert.

 

What’s The Difference Between Modvigil and Other Versions of Modafinil?

Although both Modvigil and Modalert contain the same active ingredient, the strength and additives used are different depending on who makes the drug.

HAB Pharma makes both Modvigil, and an Armodafinil generic called Waklert. This company is an ISO certified contract manufacturing company, as well as the producer of several generic drugs.

Sun Pharmaceuticals is their main competition in this market. They produce Modalert and Artvigil (an Armodafinil generic). Sun Pharmaceuticals is a much larger, international pharmaceutical company primarily operating out of the United States and India.

Both Modvigil and Modalert contain 200mg of the active ingredient, however, Modvigil is considered the weaker of the two. This isn’t a bad thing, as some people find 200mg of Provigil or Modalert too stimulating, and prefer the more subtle effects of Modvigil. This also makes it more suitable for long-term use than Modalert.

Modvigil is also cheaper than Modalert, making it more accessible to people on a budget.

 

Modvigil vs Other Study Drugs

There are other drugs that share the same classification and uses. Drugs like Adderall, Ritalin, and Dexedrine are all used to treat ADD/ADHD and narcolepsy. These drugs are also used outside the prescribed uses to improve focus and concentration.

Ritalin is classified chemically as a Methylphenidate, while Adderall and Dexedrine are classified as amphetamines. These chemicals are very different from the Afinil class of compounds despite having similar benefits.

Some of these drugs, like Ritalin and Adderall, are much more stimulating than Modafinil.

They can cause notable crashes in energy levels later in the day as the drug wears off. These drugs also tend to produce side effects involved with overstimulation. This can include anxiety, insomnia, poor appetite, teeth grinding, and paranoia. They are also more addictive in nature.

Modafinil is much less stimulating on the brain, and users tend to feel a gradual transition back to normal as the Modafinil wears off. It’s also less common to feel side effects on Modafinil.

When compared to other drugs of this class, Modafinil has been shown to have significantly fewer side effects. A recent study found fewer incidences of side effects among participants of a Modafinil treatment group compared to an Amphetamine (Adderall) group being treated for Bipolar disorder [7].

 

The Legal Status Of Modvigil

Modafinil is considered a schedule 4 controlled substance in the United States and Australia. This class is defined as substances offering medicinal benefit, but with potential for abuse. These drugs require a doctor’s prescription to purchase.

The drug is not illegal to possess, but users will not be able to purchase the drug in store or from companies based out of these countries.

Other countries, such as Canada, Finland, and Sweden have different ways of classifying drugs but places the same limitations on Modafinil as the United States and Australia.

Some parts of the world outright ban Modafinil.

Russia, Japan, and China have explicitly criminalised the use of Modafinil, punishable by varying lengths of jail sentences and/or fines if caught with the substance. You cannot buy Modafinil from most online vendors in these countries.

 

The Benefits Of Modvigil

Modvigil is a cognitive stimulant. Compared to other stimulants, however, Modvigil is considered to be much more subtle.

It works through the “orexin system” in the brain, and increases dopamine and related neurotransmitters like norepinephrine.

The orexin system plays a key role in regulating our sleep-wake cycles and dopamine, which is involved with emotion, focus, and the reward centre responsible for regulating our motivation, routines, and habits.

Modvigil helps users stay focused for longer durations when completing work or study. It helps us require fewer breaks in concentration so that we can accomplish something faster and with more precision. It essentially forces us into a flow state, which many people swear by as the best way to accomplish a job.

This makes Modvigil great for solving writer’s block, finishing tasks more quickly, cramming for a test, or getting through tedious or repetitive work.

 

The Main Benefits of Modvigil Include:

  • Improves focus and concentration
  • Boosts the creative thought process
  • Reduces the need to take breaks from work or study tasks
  • Eliminates mental fatigue for several hours
  • Forces the brain into flow states

 

The Negative Effects of Modvigil

Not all the effects of Modvigil or related products are beneficial. Understanding the negative effects is important when deciding when and how to take Modafinil.

Modvigil (and other versions of Modafinil) are so effective at boosting our focus and concentration, that in some cases it can work against us.

Sometimes when focusing so intently on one particular task, we can forget about others. It can reduce our interest in social interactions, make us forget to eat or drink, and can leave some of the other tasks we have to do unfinished.

The side effects of Modvigil includes:

  • Stomach discomfort (most common)
  • Rashes (rare but can be severe)
  • Headaches
  • Nausea
  • Anxiety
  • Insomnia
  • Dizziness

 

How Modvigil Works

Modafinil has several different effects on the brain that work together to provide the wakefulness-promoting and cognitive enhancing benefits.

Modvigil increases dopamine [1], histamine [2], norepinephrine [3], and orexin [4] levels in the brain. All of which play a part in the process of wakefulness, motivation, and concentration [1].

 

Modvigil and Dopamine

One of dopamines main roles is its involvement in the reward centre of the brain, which gives us a jolt of pleasure when we do something that benefits our body.

The reason we have this system is to build positive habits that make us want to perform a task again. This happens for activities like eating, exercising, or sex.

We also rely on dopamine for motivation and concentration. A region in our brain known as the nucleus accumbens drives this process, which is notoriously high in dopamine.

People suffering from attention deficit disorders like ADHD have been shown to have lower concentrations of dopamine than normal [5]. This means that they constantly need to stimulate their brain in order to trigger the reward centre, making it especially difficult to concentrate on or perform just one task at a time.

Dopamine reuptake inhibitors like Modafinil and other drugs like Adderall and Ritalin are used to increase dopamine concentrations in the brain to allow the reward centre to function more effectively. This makes it easier for people suffering from attention deficit disorder to concentrate.

In healthy individuals, it increases dopamine above and beyond normal levels, providing a potent boost in concentration for several hours while the drug is in effect. Once it wears off, the brain quickly returns to normal levels of dopamine.  

(Dopamine Molecule)

 

Modvigil and Histamine

What do you think of when you hear the word histamine? Most people go straight to allergies when they think of histamine.

This is because many people reach for the antihistamine drugs when they start to experience classic symptoms of allergies like a runny nose or sneezing.

There are many other uses of histamine in the human body, however.

In the brain, histamine is released from neurons connected to the control centre of the brain (the hypothalamus). It’s used to control stimulation in the brain as part of our circadian rhythm.

Studies have shown that increases in histamine release in the brain result in stimulation and changes to the sleep-wake cycle [6].

(Histamine Molecule)

 

Modvigil and Orexin

Orexin is a peptide in the brain involved with the regulation of the sleep-wake cycle, appetite, and neurostimulation [7].

People suffering from narcolepsy often have a dysfunctional orexin system. Narcolepsy is a sleeping disorder where sufferers suddenly go from a waking state to deep sleep.

Modvigil and other versions of Modafinil have been shown to increase orexin activation in the brain [4]. This is likely the mechanism behind most of the wakefulness-promoting benefits of Modafinil.

(Orexin Molecule)

 

The Cost of Modvigil

HAB Pharmaceuticals, the manufacturer of Modvigil, is well-known for their lower cost of medications.

Most suppliers of Modvigil offer different quantities of the drug, which can change the cost of the tablets.

Afinil.com, our preferred supplier of the Afinil class of drugs, offers quantities of 50, 100, 200, 300, and 500 tablets per order.

The price will vary from $1.30 USD to $0.70 USD depending on the quantity ordered.

This compares to Modalert, which ranges from $1.60 USD to $0.70 USD.

Provigil on the other hand, the brand name Modafinil, costs as much as $51 USD per tablet.

 

The History Of Modvigil

Modafinil is a benzhydryl sulfinyl compound related to Adrafinil and Armodafinil.

Adrafinil was first discovered in 1974 by a French company called Lafon Laboratories (Laboratoire Lafon). The large American pharmaceutical company Cephalon Inc later purchased Lafon Laboratories, along with the exclusive rights to manufacture Adrafinil.

Researchers later learned that Adrafinil was metabolised by the liver to produce an inactive metabolite known as modafilinic acid and the active metabolite Modafinil. They then focused on this active metabolite and produced the original version still sold today called Provigil®.

Cephalon Inc held the patent for this substance from 1990 until 2010. Once this patent expired, various other companies began manufacturing their own generic versions of the drug.

HAB Pharma came out with Modvigil shortly after, which has become one of the most popular generic versions to date.

Of course, there are other companies that also produce their own generic versions, including Teva Pharmaceuticals, Shire Pharmaceuticals, Sun Pharmaceuticals, Mylan, Barr, and Ranbaxy.

 

 

Other generic versions include:

  • Alertec
  • Alertex
  • Carim
  • Mentix
  • Modapro
  • Modasomil
  • Modiodal
  • Provake
  • Resotyl
  • Stavigile
  • Vigia
  • Vigicer
  • Vigil
  • Zalux

 

Modvigil Dose

Each Modvigil tablet contains 200 mg of Modafinil. The tablets come with a convenient crease down the centre that allows users to break the pill in half for a 100mg dose if desired.

The standard dose is one full tablet per day. This can be taken on a daily basis or one at a time to get through particularly demanding tasks. For smaller or more sensitive individuals, the 100 mg dose is often preferred.

It takes about 30 minutes for Modvigil to take effect as it’s absorbed through the small intestines and passes the blood-brain barrier. It then peaks at around the 2-3 hour mark and gradually declines from that point on.

After about 14 hours, most of the drug has been cleared from the system through the kidneys. This can vary depending on the size of the person, the health of the liver and kidneys, and what foods were consumed along with the Modvigil.

 

Conclusion

Modvigil is a great alternative to other stimulating cognitive enhancers because it has fewer side effects and tends to be less stimulating.

It’s great for those looking to increase their productivity when trying to cram for an exam, finish a tiring or fatiguing task, or get through creative blocks.

Compared to other forms of Modafinil, Modvigil is great for those who are looking for something effective but more subtle. It’s cheaper than other forms and isn’t likely to cause over stimulation. We recommend Modvigil for daily use, or for those who are looking for a gentle (but highly effective) cognitive stimulant to finish that tough project, study for that big exam, or finish tedious and mentally tasking activities.

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References:

  1. Volkow, N. D., Fowler, J. S., Logan, J., Alexoff, D., Zhu, W., Telang, F., … & Hubbard, B. (2009). Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. Jama, 301(11), 1148-1154.
  2. Ishizuka, T., Sakamoto, Y., Sakurai, T., & Yamatodani, A. (2003). Modafinil increases histamine release in the anterior hypothalamus of rats. Neuroscience letters, 339(2), 143-146.
  3. Madras, B. K., Xie, Z., Lin, Z., Jassen, A., Panas, H., Lynch, L., … & Miller, G. M. (2006). Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. Journal of Pharmacology and Experimental Therapeutics, 319(2), 561-569.
  4. Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S., & Saper, C. B. (2000). Hypothalamic arousal regions are activated during modafinil-induced wakefulness. Journal of Neuroscience, 20(22), 8620-8628.
  5. Li, D., Sham, P. C., Owen, M. J., & He, L. (2006). Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Human molecular genetics, 15(14), 2276-2284.
  6. Brown, R. E., Stevens, D. R., & Haas, H. L. (2001). The physiology of brain histamine. Progress in neurobiology, 63(6), 637-672.
  7. Nasr, S., Wendt, B., & Steiner, K. (2006). Absence of mood switch with and tolerance to modafinil: a replication study from a large private practice. Journal of affective disorders, 95(1), 111-114.

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