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Loading...People across the globe have been popping nootropics to augment their cognitive capabilities, boost their state of mental alertness, prolong their spans of attention, ameliorate their focus, be more concentrated & motivated, and certainly ameliorate their overall brain functioning.
Impressively, as the demand for efficacious nootropics is advancing, so do the analysis & development of new types of nootropic pharmaceuticals.
If you’re a fanatic of nootropics, then undoubtedly you must have heard about the most well-known, safest, efficacious, & highly used drug – modafinil, dubbed “smart tab.” Fortunately, scientists have come up with derivatives of the “smart tab” called Flmodafinil & Hydrafinil. Research on both nootropics suggests that they are more potent than their parent drug – modafinil, the king of nootropics. But how do Hydrafinil & Flmodafinil compare? Which one is better than the other? What’s their dosage? Which is the best for you?
Let’s review Hydrafinil vs. Flmodafinil in this exceptional article. We’ll make sure to fit everything that you should comprehend before determining whether to start using Hydrafinil or Flmodafinil to upregulate the brain’s working or not.
Hydrafinil Features
Hydrafinil, also identified as fluorenol, is indeed a metabolite of modafinil. It’s categorized under eugeroics – meds that foster wakefulness, & isn’t approved by the United States Food and Drug Administration (FDA) [1]. While these meds may not appear to share diverse structural resemblances, they are intimately linked to each other.
According to an analysis, Hydrafinil is certainly 39% more robust than modafinil at encouraging wakefulness in rats – supporting mice awake for 4+ hours. Regardless, after further examination, it was determined that the eugeroic action of the fluorenol analog was probably due to an active metabolite, determined as fluorenol. Certainly, fluorenol is a frail dopamine reuptake inhibitor, notably 59% frailer than modafinil, potentially pushing it even less accountable for addiction [2].
Although there are no peer-reviewed analyses on Hydrafinil as a powerful & safest nootropic, it’s indeed true that the product has equivalent eugeroic (i.e., wakefulness-ameliorating) action to modafinil, has more potent effects than modafinil (regarding alertness, overall productivity, vigilance, mood, & also memory), and remarkably influences the exact neurotransmitters in the brain as modafinil (i.e., glutamate, dopamine, & histamine).
Certainly, Hydrafinil principally operates as a dopamine reuptake inhibitor (DRI) & also as a 5-HT6 receptor antagonist. It impressively augments dopamine levels which lead to augmented cognition, enhances the concentrations of choline resulting in augmented brainpower & performance, heightens norepinephrine levels hence leading to augmented cognition, augments histamine levels in the hypothalamus hence regulating the sleep-wake cycle, and also boosts glutamate levels resulting in intensified memory & learning abilities.
With that stated, there aren’t plenty of studies that support its mode of action, but indeed, it can augment short-term visual memory, heighten concentration, & remarkably ameliorate info processing speed while reducing impulsivity & augmenting critical thinking.
Some other Hydrafinil benefits include offering insanely great alertness without the jitters [3]. It isn’t a stimulant in the traditional sense. Hydrafinil can lessen daytime fatigue. It indeed aids in easing fatigue within 30–40 minutes after ingestion in subjects with busy lifestyles [3]. This causes decision-making better manageable during the daytime.
Additionally, Hydrafinil potentially heightens wakefulness without disrupting the sleep plan. This effect can be attributed to Hydrafinil’s more mighty yet shorter-enduring time that barely stays for just about 4 to 6 hours. Besides, this nootropic is less addictive & additional efficacious than modafinil at boosting individual alertness.
Comprehensive, Hydrafinil appears to be meritorious for further investigation as a safe & super efficacious nootropic compared to others such as modafinil. How about Flmodafinil? Is it more efficacious than Hydrafinil? Continue reading.
Main Info About Flmodafinil Pills
Flmodafinil (also understood as CRL-40,940) is a eugeroic developed in the ’70s – roughly the same period that modafinil was created. It’s also administered to deliver cognitive augmenting. Nonetheless, it’s not authorized by the FDA. It’s a derivative of adrafinil & is believed to contain some discrepancies.
The CRL-40,940 is identified as bisfluoromodafinil & lauflumide [4]. It’s the bisfluoro analog or a derivative of modafinil & is remarkably considered to endure longer & have more heightened bioavailability. It’s indeed a potent eugeroic & a frail dopamine reuptake inhibitor.
According to its originators, Flmodafinil is indeed more efficacious than modafinil, more promptly absorbed, & takes a shorter duration for its exceptional effects to kick in due to it being formed from 2 fluoro-groups instead of one.
The nootropic functions by altering the levels of the neurotransmitters in the brain that regulate sleeplessness, augment alertness, & impact the wake-sleep cycle. Some of the chemicals it influences include norepinephrine, dopamine, & serotonin, among others.
Certainly, Flmodafinil is a strong cognitive-ameliorating product. Its primary benefits include augmenting alertness, heightening focus, lessening depression, augmenting memory, boosting productivity, awesome motivation, & ultimately fostering wakefulness, ameliorating mood, & wellbeing.
The great focus it offers makes you more observant, detailed, & also thorough in the execution of your work. You can easily focus & concentrate for longer hours without interruption to boost or ameliorate your productivity or an edge. The med makes you reason more clearly, recall info more accurately, & perform tasks more productively.
Flmodafinil delays or thwarts the reabsorption of dopamine & also regulates serotonin & other prime chemicals that, concurrently, convey the sensation of happiness & overall well-being. Since it heightens memory, it becomes very beneficial to seniors having a hard time remembering, i.e., as a result of Alzheimer’s condition or other forms of dementia. Note that said benefit has no scientific proof backing them up. A clinical study is required to confirm how efficacious the med is in heightening memory & the effects in the long term.
Additionally, Flmodafinil is voiced to be more potent (up to four times stronger) than the famous modafinil. Nevertheless, this isn’t verified, & there is scarcely any scientific proof to back the claim.
Remarkably, with a considerable influence on alertness, mental acuity, focus, concentration, & attention, Flmodafinil predominantly augments the quality of life & works with more suitable mental clarity.
Compare Hydrafinil and Flmodafinil
As briefly cited above, the data obtainable on both meds is relatively limited. Nonetheless, Hydrafinil & Flmodafinil are indeed efficacious eugeroics that mimic the effects of other nootropics like modafinil & Adrafinil.
Since Hydrafinil & Flmodafinil are analogs of modafinil, they function just the same in terms of alertness & wakefulness. That implies they both have identical neuropsychopharmacological properties.
The singular distinction between Hydrafinil & Flmodafinil is the negative effects & potency. Besides, Hydrafinil is believed to have a shorter half-life (4 to 6 hours) than Flmodafinill. Some individuals see Flmodafinil as enhanced modafinil. This implies that Flmodafinil will remain in your system for longer, & you’ll feel its effects for up to more than 12 hours.
This table gives a detailed view of Flmodafinil & Hydrafinil.
| Drug | Hydrafinil | Flmodafinil |
| Active component | fluorenol | CRL-40,940 |
| Dosage forms | powder or capsule | Capsule, liquid, or powder |
| Half-life | 4 to 6 hours | may have a longer half-life compared to modafinil which lasts for 12-15 hours. |
| How to take it? |
|
dose should be anywhere from one-quarter to one-half of a standard 200 mg modafinil dose.
dosage should not be taken more than 2-3 times per week when needed. |
| What is this med used for? |
|
|
| What is it also known as? | Hydroxyfluoren, fluorenol, 9-hydroxyfluorene, 9H-fluoren-9-ol, or 9-Fluorenol | Lauflamide, bisfluoromodafinil, & CRL-40,940 |
| What are they good for? |
|
|
| With what does it stack well? |
|
|
| What strengths does this med come in? | 50 to 150 mg | 50-100 mg |
| What instructions should you follow? |
|
|
| What is the half-life of this med? | 4-6 hours | it may linger in your system for longer compared to the 12–15 hours half-life of modafinil. |
| Is it effective? | extremely excellent | supremely efficacious |
| Is this a controlled substance? | no data is available at the moment | no data available |
| Is there a risk of withdrawal from this med? | no | no |
| Does this med have the possibility for misuse? | not yet declared but it’s probable | not yet remarked but it’s likely |
| What is the typical length of therapy? | long-term therapy | long-term treatment |
The table has vividly given you a comprehensive comparison between Flmodafinil and Hydrafinil. They seem to offer similar benefits & negative effects. By the looks, Flmodafinil seems to be more powerful than Hydrafinil and has a longer half-life. Nonetheless, this report hasn’t been proven, & there is hardly any scientific proof to back the claim.
Both products haven’t been authenticated by the FDA. The principal differences, though, are that Flmodafinil doesn’t have the influences of 5-HT6 receptor antagonists & that it certainly retains a longer half-life than Hydrafinil. Flmodafinil is twice the value of Hydrafinil. While Hydrafinil is about 39% stronger than modafinil, Flmodafinil is 2 to 4 times as effective as modafinil.
Additionally, unlike Hydrafinil, Flmodafinil doesn’t offer mood augmentation. Regardless, it’s most useful for obtaining more mental tasks accomplished. It doesn’t give physical energy; it’s indeed more of mental energy.
Furthermore, Hydrafinil has lower DRI impacts than Flmodafinil. That means Hydrafinil can’t block the effects of stimulants, unlike Flmodafinil.
Both meds are also non-addictive & safe. Let’s compare both nootropics based on other pointers discussed below.
Hydrafinil vs Flmodafinil: Difference Between…
Having learned about their comparisons, what is the difference between dosages, side effects, & interactions of these meds? Let’s find out.
Dosages
Both nootropics have distinct dosage guidelines. As Hydrafinil & Flmodafinil are unregulated nootropics, both don’t have any info regarding a normal dosage. A physician’s guidance is advised when administering such products to provide more authentic dosage tips.
As for Hydrafinil, commonly, manufacturers of the product prescribe standard dosing of 50 to 150 mg daily only, with no more than 150 mg a day advised. Administering the most heightened dosage for multiple days in a row isn’t advised. Overall, Hydrafinil, at present, is believed to be relatively safe to ingest due to its being compatible with other scientifically backed meds such as modafinil.
Regarding Flmodafinil, the average dose most people use is between 50 and 150 mg, though this is for individuals who’ve been administering nootropics for a long time. However, if you’re a total beginner, start with 12.5 mg-25 mg daily or 25 to 50 mg of Flmodafinil. Once your body gets familiarized with it, then maybe you can increase the dosage. Certainly, Flmodafinil dosage should not be more than 2-3 times per week when needed. Administering Flmodafinil before 10 am gives it a satisfactory time to exit your system before nighttime.
You may also consider microdosing these nootropics to experience a consistent cognitive boost & avoid side effects. As for Flmodafinil, you may consider administering small microdoses every 4 to 6 hours throughout the day. Relying on your level of experience & response to “smart drugs,” we discover that individuals can successfully microdose Flmodafinil anywhere from 3 mg to 25 mg, 4 times daily, up to 3 times a week only.
Side Effects and Safety
The deficiency of scientific analyses could not guarantee the safety of ingesting Flmodafinil & Hydrafinil. Some of the reported unfavorable reactions linked with Hydrafinil use are the following:
- nervousness;
- dizziness;
- difficulty sleeping;
- headache;
- nausea;
- a change in appetite;
- anxiety.
Flmodafinil seems to be extremely similar to Hydrafinil & other popular nootropics such as modafinil in terms of its potential negative effects. Some of its negative effects can include the following:
- upset stomach;
- headaches;
- difficulty sleeping;
- appetite;
- dizziness;
- itchiness;
- dry mouth.
Nonetheless, both nootropics are deemed to be safe & well-tolerated. Most individuals report no severe health perils. It’s generally believed to induce rarer adverse reactions than modafinil. Besides, since these nootropics haven’t gone via any human clinical tests, there is no method of comprehending the safety of their long-term use. Hence, it’s not instructed for use by pregnant or breastfeeding individuals.
Interaction with Other Meds, Food, and Alcohol
Like modafinil, Flmodafinil & Hydrafinil may have interactions with other meds such as blood thinners, certain antifungal meds, antidepressants, anti-seizure meds, & antianxiety meds. Both nootropics may have similar med interactions & others, although, at this stage, we can’t be confident [5].
Either way, individuals with any medical illnesses or those administering any prescription or over-the-counter meds that may interact with Hydrafinil & Flmodafinil are well-advised to avoid them.
Both nootropics can be administered with or without food. However, after a fat meal, the nootropic onset of action may result in a slightly more prolonged time. Don’t take these nootropics with booze. Combining them may heighten the expected negative effects.
Where to Buy These Drugs Online?
Both Hydrafinil & Flmodafinil are research chemicals. It’s difficult to discover a vendor that sells them as most of the sale is yet unlicensed, & all nootropic descriptions from such vendors point out that it’s for analysis purposes only & not meant for human consumption. You can buy Flmodafinil & Hydrafinil online via Amazon.com & other e-pharmacies — we recommend Science.bio. It’s indeed a satisfactory online place to shop for this high-quality compound. NewMind.com only offers a powdered version of Flmodafinil.
Hydrafinil vs Flmodafinil – Which Is the Best for You?
We’ve discussed in detail the difference and similarities between Hydrafinil & Flmodafinil. These nootropics are the next big nootropics to heighten your energy, mental acuity, productivity, cognition, focus, & mood. They seem to be safe and have been proven to work.
If you’re examining for safer alternative nootropics to modafinil, then Flmodafinil & Hydrafinil could be worth taking a look at. These products are indeed safe to administer, simple to obtain from the aforementioned vendors, incredibly inexpensive to purchase, & have few negative effects.
Take note that these drugs are only currently available for testing purposes.
References
- Fluorenol (pdf). Retrieved: June 22, 2022. Caymanchem.com.
- Fluorenol. Retrieved: June 22, 2022. Wikipedia.org.
- Hydrafinil Report: Nootropics. Retrieved: June 22, 2022. Reddit.com.
- CRL-40,940. Retrieved: June 22, 2022. Wikipedia.org.
- Modafinil. Last Revised: February 15, 2016. Retrieved: June 22, 2022. Medlineplus.gov.
Author Details
MBBS, MD - Psychiatry, Consultant Psychiatrist
MBBS, Doctor Of Medicine MD
Head Modafinil Researcher
