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Loading...Most robust nootropics will give us a cognitive augmentation in some form or another; yet, there are no meds or supplements obtainable at this time that can undoubtedly augment our IQ. There isn’t anything in this world that can give us telekinetic powers as well. However, nootropics are valuable for individuals looking to heighten their cognitive performance during study or work or positively support healthy brain function daily.
In this modafinil vs. Noopept review guide, we’ll explain their function in the brain, their safety, benefits, dosage & anticipated side effects, and their comparisons. We’ll also discuss where to purchase modafinil and Noopept online, & at the end of the review, we’ll give our verdict on which nootropic deserves your purpose.
Modafinil Features
Modafinil, dubbed a “smart drug,” is categorized as a stimulant & eugeroic med. It produces a feeling of being wide awake & also makes it more comfortable to focus on brain-demanding tasks.
It’s exclusively much more powerful, longer lasting, & can transform your mental state from being groggy & tired to clear-headed & super alert.
Furthermore, it’s used to influence a wakeful state within the brain. For this basis, one of the principal uses of modafinil is in the therapy of sleeping disorders like narcolepsy, shift work sleep disorder (SWSD), & obstructive sleep apnea (OSA).
Modafinil also augments dopamine concentrations in the brain by thwarting its reuptake into the synapses. These effects remarkably make it helpful for conditions involved with lower dopamine levels, such as attention deficit hyperactivity disorder (ADHD).
In healthy persons, both of these effects are employed to heighten productivity & to help individuals endure prolonged overnight sessions spent working or studying.
The “smart tab” is technically utilized to make us feel super alert & greatly wakeful. Besides, it has the secondary benefit of augmenting dopamine levels in the brain, hence inducing direct advancements in memory, learning, & concentration.
Although the “smart drug” isn’t going to provide you superintelligence, it can superbly make you a lot more effective at work — even extending the general working hours by as many as 15 or so hours!
Modafinil won’t make you feel more intelligent like the fictional drugs (NZT-48 & CPH4) in the movie Limitless do, but it will remarkably make you feel more awake & a LOT more alert & focused on the task at hand. It powers you while working on formidable & mentally tasking activities. Their memory retention is unquestionably more efficient after popping modafinil.
If you’ve problems like narcolepsy, SWSD or work-related sleep disorder, OSA, depression, post-anesthesia grogginess, chronic fatigue syndrome, jet lag, multiple sclerosis-induced fatigues, myotonic dystrophy, Alzheimer’s disease, cognitive impairment in schizophrenia, idiopathic hypersomnia, age-related memory decline, every day cat-napping, etc., then modafinil is a solution.
It’s also popularly known for its mood-brightening, relaxing, mental acuity, motivation, & memory-enhancing effects, etc. [1].
Basic Information About Noopept
Noopept is another great cognitive-heightening supplement that supports concentration + energy without the jitters & superbly ameliorates restful sleep.
It’s more typically administered as a general, all-purpose, daily nootropic supplement than substances such as Adderall, modafinil, or piracetam. It’s an extremely exhilarating brain supplement.
Noopept works by boosting acetylcholine signaling in the brain. Together, it heightens the production of nerve growth factor (NGF) & the brain-derived neurotrophic factor (BDNF) in the hippocampus, thus shielding the brain against glutamate toxicity.
Furthermore, Noopept is beneficial for treating various cognitive disorders, including cerebral vascular insufficiency, traumatic brain injury, ADHD, & age-affiliated cognitive decline.
In a nutshell, as discussed in this guide: Noopept Review in 2024: Dosage, Benefits, and Side Effects, Noopept has much additional health effectiveness. Some of them include:
- heightens memory & learning capability;
- increases sensory perception;
- heightens vision & hearing;
- ameliorates verbal proficiency & executive function;
- may ease anxiety & depression by heightening mood & help you feel better overall;
- lessens fatigue & irritability;
- decreases brain fog;
- doesn’t make you feel high: All it performs is boosted cognitive function & brain health.
Additionally, it aids during the study. Mental arithmetic + grasping complicated concepts are more straightforward with Noopept. It also augments verbal fluency. Conversation mastery might be enhanced after using it. Yes, vocabulary comes more comfortable, & you become more concentrated, which donates to a more proportional dialogue.
Compare Modafinil and Noopept
What’s your modafinil vs. Noopept experience? When it comes to how these meds augment cognition, memory, & productivity, subjectively, the impacts of these meds are identical. However, Noopept is more subtle & gentler on your liver than modafinil. Similarly, you are only required to ingest 20 mg of Noopept to acquire the effects of 100 mg of modafinil. Lesser quantities indicate less strain on the liver & also the kidneys.
Noopept is more distinct from modafinil as its effects come on much faster. The most considerable similarity between the two meds is that they both expose the user to nearly the same negative effects, which are deemed minor when the user is healthy & administers the proper dosages.
This table gives an in-depth comparison between modafinil & Noopept.
| Drug | Modafinil | Noopept |
| What form does this drug come in? | oral tab | tabs/capsules, powder, & nasal spray |
| How to take it? |
|
10 to 30 mg, relying on individual weight |
| What is this drug used for? |
|
|
| What is it also known as? | modafinil (Provigil®), armodafinil (Nuvigil®), & generics | n-phenylacetyl-l-prolylglycine ethyl ester, noopeptide, Ноопепт, & GVS-111 |
| What is it good for? |
|
|
| With what does it stack well? |
|
|
| What strengths does this drug come in? | 100-200 mg | between 10 mg to 40 mg, administered 3 times daily |
| What instructions should you follow? |
|
|
| What is the half-life of this drug? | 15 hours | 0.38 hours or 22.8 minutes. Anecdotally, its short duration of action (60–90 minutes) relies on individual weight, physiology, & dose ingested. |
| Is it effective? | excellent | good |
| Is this a controlled substance? | yes |
|
| Is there a risk of withdrawal from this drug? | no | no |
| Does this drug have the potential for misuse? | yes, prohibited by the WADA [3] | no |
| What is the typical length of treatment? | long-term therapy | short- & long-term treatment |
Compared, which is the best? It can be tough to decide on the most advantageous cognitive augmenter. You can regard alternating both meds to determine which is the best — the key to getting the most satisfactory results. When using both meds, stick to your physician’s recommendations for quality positive effects. If you need longer-lasting effects, it’s best to use modafinil because its half-life is 13+ hours.
Where to Buy These Meds Online Without Rx?
Buying modafinil and Noopept is most comfortable via the use of online vendors — it can remarkably save you a ton of money.
Places like ModafinilXL.com, BuyModafinilOnline.com, Afinil.com, FreeModafinil.org, & BuyArmodafinil.com offer extremely discounted rates on their generic modafinil.
Each vendor has unique customer price-lessening experiences, especially with the use of coupon codes, discounts, and impressive offers. Be sure to check each vendor for these money-saving experiences and apply them before checking out! Another saving experience is the use of the crypto payment option. This is indeed the huge discount ever!
Rather than carrying the pricey brand name products of modafinil like Provigil® & armodafinil, such as Nuvigil®, most online drugstores such as those mentioned above supply authentic generic versions of the med instead. They source generic modafinil from FDA-approved pharmaceuticals & mostly offer meds at the manufacturing cost.
As a note, if you are a beginner in nootropics & want to purchase modafinil or Noopept online, you ought to examine in detail the methodology of ordering nootropics, especially modafinil, in your country.
Noopept can instead be bought from places like Amazon or any other legit online store such as PureNootropics.net, a reliable & respectable source for authentic bulk nootropic products. You may also source it at Depot. The aforementioned e-pharmacies don’t stock it.
Dosage of Modafinil vs. Noopept
Noopept is sold in a tab, capsule, & powder form. Tabs & capsules are typically 10 mg each. The suggested Noopept dosage is 10 to 30 mg/day, relying on your weight. For even more immediate absorption, you can indeed use Noopept sublingual. Alternatively, let the tab or powder dissolve under your tongue so it can go directly into your bloodstream & your brain, circumventing your digestive system fully. Doing so implies it isn’t broken down when it infiltrates the bloodstream. As for intranasal Noopept, certainly it has a much more potent impact on the brain because it doesn’t get digested & isn’t metabolized.
It’s advisable to commence Noopept with approx. 5 mg or just 10 mg to assess the impact on your body. Doing so will enable you to bypass building a tolerance to the med. Observe how your body responds to it before increasing it to the standard 10 mg dose. Take note that high doses could certainly pose perils for some individuals. Be foolproof — you’re comprehensively conscious of your tolerance level before trying this.
As for modafinil dosage, the standard dosage is 200 mg. However, you may regard using the 100 mg or max. 400 mg per day. You may consider microdosing modafinil.
The advantages of microdosing are fewer minor negative effects, a more comfortable time falling asleep, & the capability to relax once the intended use is done.
You may take 50 mg of the “smart drug” in the morning alone & another 50 mg at noon. Or just 25 mg in the morning & another 25 mg after lunch. Although you take a small quantity, it still loafers you impressive cognitive augmentation & benefits.
Comparing both meds, Noopept is much stronger than modafinil. You only need a smaller dose of Noopept to achieve similar results to that of modafinil.
The Difference in Side Effects
Noopept is non-toxic. It’s well-tolerated & safe, just like modafinil, as long as you stay within the suggested dosage of both meds.
Side effects of Noopept are rare but can include fatigue, headaches, irritability, anxiety, nausea, lightheadedness, insomnia (specifically when administered at night), or stomach upset. Negative effects are frequently a result of unusually high doses. Headaches from taking Noopept normally transpire when you forget to mix it with a good supplement like choline. Headaches are generally a sign of a choline deficit in the brain.
Modafinil side effects occur based on various factors, including your health status, dosage, and body weight. Most of them are only subtle, e.g., insomnia, digestive system discomfort, low appetite, headaches, & dry mouth. Other side effects can occur [4].
Most of its negative effects are more probable to transpire with higher modafinil doses. The 50 mg dose or less rarely triggers any negative effects, while the 400 mg dose frequently begets negative effects — most typically insomnia & headaches.
Its negative effects can be controlled or lessened by ingesting the med earlier in the day, consuming enough water (2-3 L/day), & keeping adequate nutrition.
If experiencing any signs of hysteria, problem breathing, hallucinations, dizziness, or severe skin reactions, visit a physician immediately.
Are Modafinil & Noopept Interactions Different?
Give a whole list of all the meds you are using before using either modafinil or Noopept, be it prescription/nonprescription meds or herbal therapies.
As a pinpoint, don’t take modafinil or Noopept before consulting with a physician to determine if these nootropics are best for you.
Don’t take modafinil or Noopept if you are allergic to it or if you are pregnant or breastfeeding. Modafinil interactions with other meds include birth control meds, CYP3A4/5 & CYP2C19 substrates, MAO inhibitors, warfarin, illegal drugs (such as methamphetamine, MDMA, or Ecstasy), CNS stimulants, & others.
Noopept contraindications include kidney & liver dysfunction, hypersensitivity to one of the med’s components, & pregnancy + lactation.
Noopept hasn’t been broadly studied, & almost no hard proof is known regarding its probable interactions if mixed with other meds or compounds. Consequently, carefulness is admiringly advised if you select to take it while administering any other meds or supplements, as the possibility for interactions between them is nearly completely unidentified.
Modafinil can induce disease interaction if you have seizures, liver, kidneys, or heart problems, etc. [5].
Are These Nootropics Addictive?
Both meds are safe, but misusing them may make you end up developing a psychological dependence (addiction). Modafinil might indeed be habit-forming for addiction-prone individuals. Modafinil has a very low possibility for abuse or physical dependence if using higher doses over a longer time. There is low-level tolerance developed with modafinil.
Modafinil is also potentially helpful in treating individuals recovering from addiction to cocaine or other meds, e.g., methamphetamine, much in the same way methadone is frequently thought to be helpful in recovery from addiction to opiates [6]. Also, daily use of Noopept for longer periods can lead to dependency. However, it’s non-addictive with a low prospect for abuse.
Conclusion
Which is the supreme nootropic for your desired purpose? From problem-solving to motivation and from concentration to memory, both modafinil & Noopept provides broad-action augmentation across a spectrum of cognitive attributes. Either of the meds can be used to heighten wakefulness, enhance productivity, & impressively gain more in cognitive tasks. All in all, we can conclude that modafinil is a powerhouse when it comes to cognitive-augmenting effects. It has been widely studied to be safe & very efficacious.
References
- The off-prescription use of modafinil: An online survey of perceived risks and benefits. By Rachel D. Teodorini, Nicola Rycroft, and James H. Smith-Spark. Published: February 5, 2020. Journals.plos.org.
- N-Phenylacetyl-L-prolylglycine ethyl ester. Retrieved: September 9, 2022. Wikipedia.org.
- The Prohibited List. Retrieved: September 9, 2022. Wada-ama.org.
- Modafinil Side Effects by Likelihood and Severity. Retrieved: September 9, 2022. Webmd.com.
- Modafinil Disease Interactions. Retrieved: September 9, 2022. Drugs.com.
- Modafinil Uses, Side Effects & Addiction Treatment By Editorial Staff. Updated Sep 8, 2022. Americanaddictioncenters.org.
Author Details
MBBS, MD - Psychiatry, Consultant Psychiatrist
MBBS, Doctor Of Medicine MD
Head Modafinil Researcher
