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Hydrafinil vs Modafinil: Which Is Better in 2022?

Everyone desires to be smarter & awesomely be faster to be competent to cope with the competitive edge in the globe. If you’ve heard about or watched the great movie ‘Limitless,’ you’ll certainly want a tablet similar to the med mentioned in the movie that makes Bradley Cooper super invincible!

Hydrafinil vs Modafinil

However, while the tab in the movie doesn’t genuinely exist in the real world, some products come adorable close to it – Modafinil & Hydrafinil. They are nootropics. A lot of nootropic enthusiasts are eager to know how these meds compare. This guide is all about Hydrafinil vs modafinil. It covers everything you should comprehend regarding their similarities, differences, dosages, interactions & negative effects, & where to buy them online from the most impressive e-pharmacies.

What Is Modafinil?

Modafinil dubbed “smart tab” belongs to the eugeroics class of meds. It works to augment brain function, making us feel alert & wakeful. It’s produced by Cephalon, and it was approved by the FDA in 1998 as a prescription to remedy sleep disorder conditions linked with shift work sleep disorder, narcolepsy, or obstructive sleep apnea.

Besides, the “smart tab” can be prescribed off-label by physicians for conditions like attention deficit hyperactivity disorder, dementia, major depressive disorder, chronic fatigue syndrome, weight loss, Alzheimer’s & Parkinson’s disease, among other health conditions.

Besides, a high rate of healthy individuals, such as CEOs, executives, students, astronauts, & military personnel, use the “smart tab” as a potent med to ameliorate their cognitive capabilities & remarkably augment productivity. Also, several individuals across the globe use the “smart tab” due to the fear of academic loss, the longing to meet high work needs, & to crush procrastination.

Modafinil undoubtedly heightens cognitive functions, i.e., learning, concentration, thinking, mental acuity, vigilance, positive energy, perception, productivity and drive, alertness, motivation, focus, attention, augmented mental stamina or endurance, & also greater interest in work, etc. Just like stimulants, the “smart tab” influences the mind, inducing various cognitive advantages.

Modafinil White Pills

There are many other advantages of modafinil. It’s well absorbed, attaining peak plasma concentration between 2–4 hours after ingestion & has a half-life of approx. 12–15 hours [1].

What Is Hydrafinil?

Hydrafinil (9-fluorenol or fluorenol) is certainly a metabolite of modafinil. It was created by Cephalon Pharmaceuticals as a potential successor to the famous eugeroic med Provigil, also understood as modafinil. It’s categorized under eugeroics – medications that heighten wakefulness [2]. While Hydrafinil & modafinil may not seem to share myriad structural similarities, they are discreetly linked to each other. Research demonstrated that it’s 39% more influential than modafinil at augmenting wakefulness in rats. Fluorenol is a frail dopamine reuptake inhibitor, a remarkable 59% weaker than modafinil, possibly making it even less probable for addiction [3].

Compare Modafinil and Hydrafinil

Although there aren’t peer-reviewed investigations on Hydrafinil as an influential nootropic, it’s confirmed that the med retains the following properties compared to modafinil:

  • it has equivalent eugeroic (i.e., wakefulness-ameliorating) action to modafinil;
  • it remarkably impacts the identical neurotransmitters in the brain as modafinil (i.e., glutamate, serotonin, dopamine, & histamine);
  • it’s presumably more potent than modafinil regarding overall productivity, mood, alertness, vigilance, & memory;
  • it’s remarkably less addictive & extra productive than modafinil at boosting alertness;
  • similar to modafinil, it’s undoubtedly not a stimulant in the conventional sense. It’s indeed a weak DRI, signifying that it’s apt to intensify alertness with an inconsequential risk of addiction;
  • similar to modafinil, it might make an individual experience augmented sex drive due to its supplementary focus, which directs to ameliorated sexual experience. Exceptionally, it can amplify focus on the delights of sex — instead of the distractions — if you’re exclusively in the right frame of mind.

Besides, modafinil triggers psychoactive & euphoric effects and alterations in thinking, feelings, mood, & perception. Since Hydrafinil is 39% more potent, it’s likely to be more euphoric than modafinil.

So which is better than the other? Here’s a table that further depicts the comparisons between Modafinil & Hydrafinil:

Drug Modafinil Hydrafinil
What form does this nootropic come in? oral tab powder & capsule
How to take it?
  • take once in 24 hours for treating sleep disorder conditions;
  • administered as required if using it for productivity + cognitive-ameliorating effects (40 minutes to an hour for a scheduled task).
  • a max. of 150 mg of powder can be ingested in hourly intervals;
  • cautiousness should be exerted. Don’t administer too much of it due to its heightened strength.
What is this med used for?
  • can be used to foster wakefulness in individuals with narcolepsy, OSA, or SWSD as well as other related conditions, although it’s not yet endorsed;
  • as a brainpower booster.
What is it also known as? Provigil® & several generic brands 9-fluorenol, fluorenol, 9H-Fluoren-9-ol, & 9-Hydroxyfluorene
What is it good for?
  • mental focus;
  • alertness;
  • energy;
  • agility;
  • motivation;
  • cognition.
  • alertness without the jitters;
  • daytime fatigue;
  • wakefulness;
  • motivation;
  • energy;
  • cognition;
  • memory;
  • focus.
With what does it stack well?
  • Noopept;
  • Piracetam;
  • choline;
  • fish oil;
  • Ashwagandha;
  • Phenibut;
  • Phenylpiracetam;
  • Bacopa;
  • L-Theanine, etc.
  • choline;
  • fish oil;
  • Ashwagandha;
  • Noopept;
  • Piracetam;
  • Bacopa;
  • Phenylpiracetam;
  • L-Theanine;
  • Phenibut, etc.
What strengths does this med come in? 100-200 mg 50-100 mg
What instructions should you follow?
  • take with or without food;
  • after a fat meal may result in a little longer time to start working;
  • it’s most useful to bypass alcohol.
  • take with or without food;
  • after a fat meal may result in a little longer time to start working;
  • circumvent mixing it with alcohol.
What is the half-life of this med? 12-15 hours 6 to 8 hours
Is it efficacious? excellent exceptional
Is this a controlled substance? yes doesn’t currently have the U.S. Food and Drug Administration approval
Is there a risk of withdrawal from this med? no no
Does this med have the potential for misuse? yes, prohibited by the WADA [4] no data exist
What is the typical length of treatment? long-term therapy is generally long-term therapy

Overall, Hydrafinil deserves further analysis as an outstanding choice for modafinil. Since it’s still under study, it indeed can produce more influential cognitive augmentation than the prominent modafinil at a lower dose, without some of the negative reactions linked with modafinil.

Modafinil vs Hydrafinil: Difference Between…

Unlike modafinil, Hydrafinil is NOT approved by the Food and Drug Administration (FDA), nor is it administered to treat any of the sleep disorders for which modafinil is prescribed [5]. Without FDA authorization, its strength & safety profile isn’t strictly regulated, so it is most reasonable to approach its use with extreme caution. Also, it doesn’t stay long in the body, thereby benefiting a satisfactory night’s sleep.

Let’s explore more between their dosage, negative effects, & interaction.


As noted earlier, Hydrafinil is deemed 39% more influential than modafinil. In simple math, this implies that Hydrafinil 50 to 100 mg dose equals 100 to 200 mg of modafinil.

Because there are yet more scientific investigations required to confine the exact Hydrafinil dosage, it’s great to employ the compound, obtainable in the form of powder or capsules, in the dose of 50 to 150 mg. A max. of 150 mg of Hydrafinil powder can be administered in hourly intervals. Additionally, vigilance should be exerted to not consume too much of it due to its high strength.

The physician’s counsel is very important to adhere to when taking such a product to obtain more precise dosage recommendations.

Ingesting the highest dosage of Hydrafinil for many days in a row isn’t prudent. Sticking to a 50 mg dose is certainly safe, since it’s unlikely to induce any negative effects. Besides, if taking 50 mg isn’t giving you the anticipated effects, consult a physician before opting to raise the dosage.

Modafinil dosage is well studied, and it’s advisable to use 200 mg. However, based on the outcome, it can be increased to max. 400 mg or lower to 100 mg or so.

Side Effects and Safety

Unlike other popular eugeroics, Hydrafinil & modafinil have few negative effects & are considered to be the safest & potent pharmaceutical options available. Further, Hydrafinil is less addictive compared to modafinil, & it can even aid some users to get over dependencies or addictions.

Side Effects

On the other hand, the lack of scientific investigations about Hydrafinil could not assure the safety of its usage. Similar to modafinil’s negative effects, some of the reported unfavorable reactions linked with Hydrafinil use are the following:

  • a change in appetite;
  • dizziness;
  • hardship sleeping;
  • headache;
  • nervousness;
  • nausea;
  • anxiety.

Because the FDA doesn’t regulate Hydrafinil compound, extreme caution must be exercised. Other negative effects of both Hydrafinil and modafinil can exist. However, most individuals who have used Hydrafinil report no extreme health risks. It’s typically contemplated to induce more infrequent adverse reactions than modafinil. Since Hydrafinil hasn’t gone through any human clinical trials at the time of writing this guide, there is no way of fathoming the safety of its long-term use. Therefore, it’s not suggested for use by those who are either pregnant or breastfeeding.

Interaction with Food and Alcohol & Other Meds

Given the scarcity of scientific analysis on Hydrafinil to date, you might be inquisitive about its interactions with other meds or food.

The medications that may interact with Hydrafinil aren’t comprehended at the moment because it hasn’t been broadly investigated in humans. This implies we don’t genuinely comprehend the possible drug interactions but be certain that it might have similar drug interactions like that of modafinil & other meds. That means any substance that hasn’t been well studied in humans is dangerous to ingest. Always make sure you don’t mix Hydrafinil with other meds. Be certain to check the possibilities of modafinil interactions with other meds such as warfarin, CYP3A4/5 & CYP2C19 substrates, birth control meds, CNS stimulants, and MAO inhibitors, etc., since it’s structurally related to modafinil. Both nootropics can be taken with or without food. However, taking then a fat meal may result in a little longer time to start working. Also, circumvent mixing any of the nootropics with alcohol. Alcohol & Hydrafinil or modafinil have opposite effects on chemistry in the brain. It may display severe negative effects that necessitate prompt medical attention.

Where to Buy These Drugs Online?

There are many places online to purchase Hydrafinil. Relying on your pursuit with this eugeroic, you desire to confirm that you shop from a legit vendor that cares about safety, viability, strength, as well as transparency & no shipping hurdles. In this case, we suggest Science.bio. It’s undoubtedly a good site to shop for real Hydrafinil. Also, Hydrafinil is commonly obtainable at a lower price than modafinil.

Certainly, despite being a new firm, Science.bio has remarkably thrived in affirming itself as a favorably trustworthy supplier of premium-quality investigation compounds like Hydrafinil. It furnishes outstanding shopper service & has comprehensive transparency regarding its product quality. Each chemical offered by this great vendor is rigorously verified & comprises a comprehensive data sheet + exhaustive audits of production batches.

Hydrafinil can also be bought via Amazon.

How about modafinil? Certainly, if you still desire to try an exclusive well-researched nootropic that’s remarkably safe & extremely influential for most users, you can shop modafinil online. Get generic modafinil from reliable e-drugstores that offer it at an extremely low cost. Their generic modafinil meds are sourced from certified manufacturers. The suggested modafinil vendors are ModafinilXL.com, BuyModafinilOnline.com, HighStreetPharma.com, & BuyModa.org. These e-drugstores are legit, very reliable, & have exceptional shopper reviews & testimonials since they fulfill what they pledge, providing speedy parcel delivery, excellent shopper support, a refund policy, & impressive profitable drug prices with the use of coupon codes, offers, & huge discounts.

The Verdict: Hydrafinil vs Modafinil

As discussed in this insanely great guide, determining which nootropic is most suitable for you will rely on what you intend to use it for. You’ve read and comprehended the difference and comparison between modafinil & Hydrafinil. From studies, it’s believed Hydrafinil is slightly more powerful compared to modafinil & once approved for use; more enthusiasts will certainly desire it.

For now, if you’re examining for intensified productivity, heightened focus, impressive positive mood & motivation, clearer thinking, or heightened reaction time without some negative effects linked with strong stimulants like Adderall, we believe Hydrafinil is a more satisfactory option.

However, if you just want an outstanding nootropic that has been extensively researched & scientists have called it the globe’s first safe “smart tab,” then modafinil should be your choice. Buy modafinil from top-rated vendors including BuyModafinilOnline, HighStreetPharma, ModafinilXL, & BuyModa. These vendors offer it at an extremely low cost.


  1. The off-prescription use of modafinil: An online survey of perceived risks and benefits. By Rachel D. Teodorini, Nicola Rycroft, and James H. Smith-Spark. Published: February 5, 2020. Journals.plos.org.
  2. Product Information (pdf). Retrieved: May 8, 2022. Caymanchem.com.
  3. Fluorenol. Retrieved: May 8, 2022. Wikipedia.org.
  4. The Prohibited List. Retrieved: May 8, 2022. Wada-ama.org.
  5. Modafinil – Uses, Side Effects, and More. Retrieved: May 8, 2022. Webmd.com.

Modafinil.org is an informational resource about modafinil and other nootropics.