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Modafinil History: When Was “Smart Drug” Created?

Globally, millions of nootropic enthusiasts regularly purchase modafinil online for various reasons, for example, to make more money or climb the corporate ladder. But only a few individuals are aware of what the med is or where it originated from. That’s why in this vivid post, we’ll examine the origin of modafinil & how it became the world’s most sought-after “smart tab.” We’ll also discuss the modafinil history, who discovered it, why it was created, & why it’s the go-to cognitive-augmenting product for hundreds of hard-working students, business executives, & professionals around the globe.

Modafinil History

Continue reading to get real information on where you can get some modafinil tabs for yourself.

When Was Modafinil Created?

In 1974, two ingenious scientists (Jouvet & Bastuji) working for the French pharmaceutical company Laboratoire L. Lafon found a molecule termed adrafinil. Early examination of this chemical showed that it acted as a eugeroic or a wakefulness-fostering agent.

Adrafinil was trialed as a med for narcolepsy, but these trials weren’t successful. This led to the discovery of its active metabolite – modafinil. Unlike adrafinil, modafinil turned out to be remarkably powerful at treating narcolepsy. In 1983, Jouvet & Bastuji prescribed this drug to patients suffering from narcolepsy & idiopathic hypersomnia and achieved a notable decrease of excessive daytime sleepiness & sleep attacks in a majority of subjects. Although the company Laboratoire L. Lafon didn’t plan to develop this molecule for the market, thanks to Jouvet’s insistence, it agreed to begin clinical trials in healthy volunteers and narcoleptic subjects as well as to conduct animal studies. The results were excellent [1].

In 1986, modafinil was offered as an innovative narcolepsy treatment. It was found to significantly heighten the production of several essential neurotransmitters in the brain, such as norepinephrine, serotonin, histamine, dopamine, & orexin systems. Modafinil had a dramatic effect on the user’s capability to stay awake & alert for a long time.

The drug was originally released in France under the brand name Modiodal in 1994 & was soon offered throughout Europe and globally during the 1990s & early 2000s.

Pharmaceuticals & Prescriptions

Cephalon, now part of Teva Pharmaceutical Industries Ltd., the world’s largest generic med maker, obtained modafinil approval after the med entered the USA. It was certified by the Food and Drug Administration (FDA) in 1998 under the brand name Provigil for the treatment of narcolepsy. In 2003, the FDA extended the approval, allowing it to be prescribed to treat shift work sleep disorder (SWSD) & obstructive sleep apnea (OSA) [2].

Teva Pharmaceutical Industries

Now physicians prescribe modafinil off-label to treat other health conditions, including Parkinson’s & Alzheimer’s diseases, depression, attention deficit hyperactivity disorder (ADHD), multiple sclerosis fatigue, age-related memory decline, idiopathic hypersomnia, cognitive impairment in schizophrenia, post-anesthesia grogginess, myotonic dystrophy, everyday cat-napping, jet lag, etc. [3].

After the patent on the branded drug Provigil expired, various pharmaceutical companies across the globe started to produce their own generic versions of modafinil. Generic meds usually work the same as brand-name drugs. For them to be approved, they should have the same dosage, effectiveness, safety, quality, and mode of administration as their branded counterparts.

Several generic versions of Provigil have been certified by the FDA. The following pharmaceutical companies produce generic modafinil products that are equivalent to the branded drug [4]:

Manufacturer Approval Date
Alembic Pharmaceuticals Ltd. October 18, 2012
Orchid Healthcare September 26, 2012
Aurobindo Pharma Ltd. September 27, 2012
Cadila Pharmaceuticals September 14, 2017
Apotex Inc. February 3, 2014
Watson Labs Inc. November 1, 2012

Provigil is extremely expensive, and not everyone can afford it. The good news is that there are several other generic drug makers from India, aside from the ones mentioned above, that produce super cheap modafinil generics. Some of the manufacturers include Centurion Laboratories, Intas Pharmaceuticals, Healing Pharma, & HAB Pharma. It’s better to opt for generic modafinil meds that are as safe & effective as Provigil but are much cheaper. Besides, they are widely accessible, so it’s easy to buy them online. Here are some of the popular generic modafinil brands:

After modafinil was approved, it swiftly earned a reputation for its off-label cognitive benefits. It was found to heighten the levels of dopamine in the brain, thus improving mood & overall sense of well-being [5]. Another study depicts that it has a positive effect on working memory & overall cognition [6].

Some other modafinil’s scientifically-proven cognitive effects are as follows:

  • heightened attention span [7];
  • improved focus & concentration;
  • reduced fatigue [8];
  • enhanced executive functions;
  • ameliorated planning and decision-making [6].

Grad students, CEOs, astronauts, military personnel, athletes, & entrepreneurs, among other professionals, now use this nootropic for various reasons, for example, to boost their productivity in the workplace or to gain a competitive edge, and find it extremely effective.

Modafinil Is the World’s First Safe Smart Drug

Modafinil’s rise to become the world’s #1 “smart tab” has a lot to do with American lifestyle guru Dave Asprey. He established Bulletproof 360 in 2013 & started inspiring people to hack their brains. He extolled the virtues of nootropics, particularly modafinil.

Modafinil Smart Drugs

According to Asprey, he has taken modafinil for 8 years, including his time at Wharton Business School. As his fame grew, the word about the “smart tab” began getting out. While Dave didn’t sell the med, he aided in popularizing it & bringing it into the mainstream. The highly effective “smart tab” swiftly became the new form of Adderall. Over time, more & more individuals began using it to ameliorate their minds & reach their goals.

Also, modafinil was dubbed the “world’s first safe ‘smart tab’” by researchers at Oxford & Harvard universities due to its low-risk effects when used in the short term. However, like any other pharmaceutical drug, it can cause mild negative effects like headaches, insomnia, & dizziness that usually fade away after a while. While researching, the scientists reviewed about 24 studies looking at the nootropic’s effect on cognitive amelioration, publishing their groundbreaking work in the journal European Neuropsychopharmacology. Based on their conclusion, modafinil has significant cognitive benefits & vanishingly few negative effects [9].

How to Buy Modafinil Online?

Now, you can easily purchase modafinil online either for promoting wakefulness or for improving cognitive abilities. The number of e-pharmacies selling modafinil to “smart tab” enthusiasts is rapidly increasing. Certainly, it’s easier than ever before, and the prices + shipping times have never been better. However, it can be hard to choose the right vendor that fulfills all your shopping needs. Fraudulent e-pharmacies may sell illegal generic versions of Provigil. Such meds may be counterfeit & possibly unsafe. If you purchase meds online, be sure to get them from a legal, reputable vendor.

Among several legit e-pharmacies, we’ve discovered that ModafinilXL.com, BuyModa.org, FreeModafinil.org, BuyModafinilOnline.com, Afinil.com, and BuyArmodafinil.com are the best vendors in the industry. These e-pharmacies operate insanely great, sourcing their meds from certified pharmaceutical companies that make high-quality products. They offer great prices on modafinil generics, ultra-fast shipping, & guaranteed delivery to any part of the world.

Final Thoughts: History of Modafinil

Hopefully, this guide has answered all your questions if you were curious about modafinil history as well as its synthesis. We’ve covered the prime pointers – from what the med is to its benefits & where to get some pills online. Get your hands on the world’s most robust “smart tab.” More & more individuals are becoming aware of the positive effects modafinil has on their cognitive performance & certainly their overall well-being. Aside from various professionals, students are also beginning to hack their brains. According to Dave Asprey, there are numerous stories about students using the “smart tab” to get an edge on their schoolmates.

References

  1. Modafinil: its discovery, the early European and North American experience in the treatment of narcolepsy and idiopathic hypersomnia, and its subsequent use in other medical conditions. By Michel Billiard and Roger Broughton. Published: September 2018. Pubmed.ncbi.nlm.nih.gov.
  2. Modafinil. Retrieved: November 5, 2021. Wikipedia.org.
  3. Practical Use and Risk of Modafinil, a Novel Waking Drug. By Dongsoo Kim. Published: February 22, 2012. Ncbi.nlm.nih.gov.
  4. Generic Provigil Availability. Updated: October 6, 2021. Retrieved: November 5, 2021. Drugs.com.
  5. Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain: Clinical Implications. By Nora D. Volkow, Joanna S. Fowler, Jean Logan, et al. Published: March 18, 2010. Ncbi.nlm.nih.gov.
  6. Effects of Modafinil on Non-Verbal Cognition, Task Enjoyment, and Creative Thinking in Healthy Volunteers. By U. Müller, B. Rowe, T. Rittman, et al. Published: January 2013. Sciencedirect.com.
  7. Mechanisms of modafinil: A review of current research. By Paul Gerrard and Robert Malcolm. Published: June 2007. Ncbi.nlm.nih.gov.
  8. Modafinil, d-amphetamine, and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance, and body temperature. By R. Pigeau, P. Naitoh, A. Buguet, et al. Published: December 1995. Pubmed.ncbi.nlm.nih.gov.
  9. Systematic review shows ‘smart drug’ modafinil does enhance cognition. Published: August 19, 2015. Eurekalert.org.

Modafinil.org is an informational resource about modafinil and other nootropics.