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Oxiracetam vs. Modafinil: Which Nootropic Drug Is Better?

Looking to tap into the phenomenon of nootropics & unlock your brain’s maximum potential? Want that superb competitive edge? Oxiracetam & modafinil are some of the nootropics that might do the job. But how safe & efficacious are these meds?

Oxiracetam vs. Modafinil

Here’s Oxiracetam vs. modafinil guide. Is Oxiracetam better than modafinil? Is there any difference between these nootropics? In this review, we’ll answer these queries & more by clarifying how they function, how they compare, their dosage & negative effects, & more. Read it to know which nootropic gives you a superb competitive edge with the benefits you earnestly needed.

What Are Modafinil Drugs?

Modafinil dubbed “smart tab” is undoubtedly the most well-known nootropic tablet on the market. It was created in France from the ashes of a narcolepsy med dubbed Adrafinil, which was unpopular because it took so long to function in the body. Chemists recognized they could cut down wait duration by synthesizing the chemical that’s born out of metabolized Adrafinil—& that turned out to be modafinil. Adrafinil was terminated in 2011.

The modafinil researchers seem self-confident to label it as the globe’s first-ever verified safe & powerful cognitive-augmenting tab that’s only uncontroversial if applied by healthy individuals. Those influenced by sleep disorders such as narcolepsy, shift work sleep disorder, & obstructive sleep apnea are also given this med as a prescription. The Food and Drug Administration (FDA) approves it for said sleep disorders.

It’s marketed by Cephalon Inc. under the brand name Provigil® among others. Certainly, it’s a stimulant-like med. According to Scientific American, it has passed diligent rigorous examinations of cognitive advancement [1].

Physicians consider prescribing the “smart tab” off-label for other sleep disorder-related conditions & for certain health concerns, including depression, ADD/ADHD, cognitive impairment in schizophrenia, jet lag, multiple sclerosis-induced fatigues, idiopathic hypersomnia, Alzheimer’s disease, weight loss, myotonic dystrophy, chronic fatigue syndrome, everyday cat-napping, age-related memory decline, post-anesthesia grogginess, & other related conditions.

Certainly, due to its safeness profile, a “smart tab” can be administered by any healthy person desiring to function late (for extended hours), heighten their cognitive responses, & stay open-eyed during lengthy missions or assignments that mandate several hours, or to brighten their positive moods.

Overall, modafinil augments individual cognitive power, specifically “higher” brain functions that certainly depend on collection from multiple uncomplicated cognitive processes. A new systematic analysis demonstrates that the “smart tab” does undoubtedly bestow influential cognitive advantages on healthy individuals, at least on a distinct subset of tasks [2].

What Is Oxiracetam?

Oxiracetam ((S)-Oxiracetam) is certainly a water-soluble ampakine nootropic in the racetam category of blends. It’s indeed considerably more powerful than the authentic racetam, Piracetam [3].

Oxiracetam

Undoubtedly, Oxiracetam became the 3rd racetam nootropic & was created in the 1970s. It’s chemically emanated from Piracetam where the major discrepancy is simply the addition of a hydroxyl group. Certainly, Oxiracetam, comparable to other racetam nootropics, contains a pyrrolidone nucleus at its core.

In this regard, Oxiracetam indeed modulates AMPA-sensitive glutamate receptors & remarkably heightens neurotransmitter release [4].

Enthusiasts use this nootropic to heighten memory & learning, aid brain health, & for its mild stimulant effects.

Oxiracetam comes with a lot of benefits. It optimizes brain function by significantly ameliorating sensory perception, cognition & memory, & reflexes. It also boosts individual concentration, offers great focus, & indeed memory recall becomes easier.

Besides, Oxiracetam augments the choline-acetyltransferase (ChAT) enzyme available in the brain [5]. This critical enzyme is remarkably trustworthy for acetylcholine (ACh), a neurotransmitter essential for encoding current memories, attention, reasoning, cognition, & also neuroplasticity.

Additionally, Oxiracetam heightens brain energy. It also modulates AMPA receptors. In this regard, ampakines furnish a stimulant effect by impacting glutamate receptors [6]. Oxiracetam also appears to heighten ATP synthesis in brain cells [7].

What’s more? Indeed, Oxiracetam is regarded to be more powerful than Piracetam. It impressively aids heighten attention span & alertness, as well as augments memory. Including the capability to create long-term memories even if administered after the initial memory formation [8].

The outstanding benefit of Oxiracetam is that it heightens memory & cognition. Clinical studies have examined using Oxiracetam to therapy ADHD, dementia, Alzheimer’s, Traumatic brain injury (TBI), concussions, & other brain disorders. Certainly, many of these trials indicated Oxiracetam’s capability to ameliorate spatial learning performance, memory, recall, + quality of life scores.

It indeed functions similar to other racetams by targeting the ACh & glutamate neurotransmitters. Remarkably, ACh has an influential consequence on memory formation & even recall. Additionally, glutamate plays a great function in memory formation, augmenting motivation & attention.

Compare Modafinil and Oxiracetam

In popular culture, modafinil is considered the “closest real-life version of the Limitless tab” depicted in the Limitless movie. Its mode of action is centered on augmenting several fundamental excitatory neurotransmitters (serotonin, orexin, norepinephrine, dopamine, histamine, & glutamate), as well as loosening GABA, the primary inhibitory neurotransmitter.

This table further compares modafinil and Oxiracetam.

Drug Modafinil Oxiracetam
Active component modafinil (S)-Oxiracetam
Dosage form oral tab sold in a tab, capsule, & powder form.
How to take it?
  • ingested once daily (in 24 hours) for treating various sleep disorders;
  • ingested as needed for productivity & cognitive-ameliorating effects (44 minutes to an hour for a scheduled task).
the suggested dosage is 750 – 1,500 mg daily. Divided into 2 equal doses. One dose in the morning & one in the early afternoon.
What is this med used for?
  • heighten wakefulness in individuals with OSA, narcolepsy, or SWSD, & also other related conditions;
  • as a robust cognitive augmenter.
to therapy ADHD, dementia, Alzheimer’s, Traumatic brain injury (TBI), concussions, & other brain disorders.
What is it also known as?
  • armodafinil (Nuvigil®) & generics;
  • modafinil (Provigil®) & generics.
doesn’t have other forms
What are they good for?
  • mental focus;
  • motivation;
  • mental acuity;
  • energy;
  • alertness;
  • agility;
  • cognition.
  • heighten attention span, energy, motivation, memory, recall, alertness, as well as augmented focus;
  • greatly ameliorate the logical, decision-making ability of the mind.
With what does it stack well?
  • Noopept;
  • Bacopa;
  • fish oil;
  • Ashwagandha;
  • Piracetam;
  • Choline;
  • Phenylpiracetam;
  • Phenibut;
  • L-Theanine, etc.
  • Alpha GPC;
  • CDP Choline;
  • modafinil;
  • Piracetam;
  • Citicoline;
  • Aniracetam;
  • Adrafinil;
  • Noopept;
  • Sulbutiamine, etc.
What strengths does this med come in? 100-200 mg tabs & capsules usually 750 mg each.
What instructions should you follow?
  • pop with or without food;
  • after a fat meal may result in a slightly more prolonged duration to start functioning;
  • it’s most suitable to bypass alcohol.
  • administered with or without food;
  • after a fat meal may result in a slightly more prolonged time to begin functioning;
  • bypass combining it with booze.
What is the half-life of this med? 15 hours in healthy individuals, it’s about 8 hours, whereas it’s about 10–68 hours in patients diagnosed with renal impairment.
Is it effective? extremely excellent good
Is this a controlled substance? yes
  • not included in the schedules of the CDSA & indeed isn’t a controlled substance;
  • not scheduled by the U.S. Food and Drug Administration.
Is there a risk of withdrawal from this med? no no
Does this med have the possibility for misuse? yes, prohibited by the WADA [9] no
What is the typical length of therapy? long-term therapy short & long-term therapy [10]

Though there is no confirmed investigation on Oxiracetam’s effect on youthful, healthy individual subjects, it’s certainly a widespread nootropic considered by many to heighten various cognitive aspects such as learning ability, memory, & overall cognition, regardless of individual age or cognitive condition.

Unlike modafinil, Oxiracetam hasn’t been explicitly authorized for any specific use by the United States FDA. Certainly, Oxiracetam is presently unregulated in the USA, Australia, Canada, & the UK.

Compared to modafinil, Oxiracetam is indeed safe & non-toxic even at high doses, & it’s linked with virtually no serious negative effects. The nootropic is extremely useful for individuals suffering from deficiency of energy, the inability to focus, & brain fog.

An exceptional bonus: If you require some serious cognitive benefits such as needing studying motivation, super focus, insanely great energy, mental acuity, or need to acquire seriously productive at work, stacking Oxiracetam with modafinil undoubtedly can be highly efficacious. Combining the mental energy, motivation, alertness, drive, & clarity of modafinil with the brainpower enhancement of Oxiracetam is indeed a robust mix for students, professionals, business people, & CEOs in competitive industries. Another option is to stack Oxiracetam with Adrafinil if you can’t obtain modafinil in your country.

Continue reading to know where you can buy these nootropics online.

Where to Buy These Meds Online Without Rx?

If you desire to relish the cognitive benefits of nootropics & are prepared to order them online, regard that several e-pharmacies offer modafinil & Oxiracetam for sale. Nonetheless, there is a possibility of counterfeit meds, & you should not just order your med from any online pharmacy without considering if it’s legit or rogue. The preponderance of e-drugstores sells modafinil & other great nootropic meds without a prescription.

Choose an Online Pharmacy

Stay safe, there can be various legit e-pharmacies, but we specifically recommend ordering your generic modafinil at extremely low cost & having it delivered to your location without any problems at ModafinilXL, BuyModafinilOnline.com, Afinil.com, FreeModafinil.org, & BuyArmodafinil.com.

These e-pharmacies operate similarly & seem to have similar drug pricing & shipping time.

ModafinilXL (MXL) has existed as one of the greatest-rated modafinil e-pharmacy across the globe. So far, it has tons of optimistic reviews & testimonials on sites like Reddit, Trustpilot, & other forums. MXL takes the lead in providing generic modafinil meds. That implies you can save a ton of money by using its insanely great price-lessening strategies, such as the use of discounts, coupon codes, & offers. Its parcel shipping is swift to most parts of the globe, including the USA, Malaysia, Ireland, Australia, UK, EU countries, Hong Kong, Singapore, etc.

BuyModafinilOnline (BMO) is another great e-pharmacy to buy modafinil at pocket-friendly prices, plus the use of discounts & coupon codes. Honestly, BMO is a sister e-drugstore to MXL – a trustworthy & top-rated “smart tab” vendor with over 600,000 satisfied shoppers. We strongly recommend BMO for shoppers purchasing from the European Union, Singapore, the US, the UK, Australia, & also Hong Kong. The vendor guarantees delivery & secure checkout.

Another e-pharmacy, BuyArmodafinil (BA), is a sister to MXL & operates as a low-cost “smart tab” e-pharmacy. The e-pharmacy strives to furnish its shoppers with safe & efficacious meds. It indeed partners with India’s biggest nootropic manufacturers such as Centurion, Sun Pharma & Hab Pharma, and Healing Pharma to offer its shoppers top-quality generic “smart tabs,” including Modalert, Armodavinil, Artvigil, Waklert, & Modvigil.

Like BA, FreeModafinil focuses on speedy delivery of modafinil at a low cost. It offers the convenience of modafinil online ordering & delivery. Besides, it delivers directly from India to the shopper’s home by mail & offers full refunds or reshipment in case of any parcel failed delivery, just like the above-mentioned e-pharmacies do.

Finally, Afinil.com has similar operations to the aforementioned e-pharmacies. It’s indeed the one-stop-shop digital drugstore of your time for authentic low-cost “smart tabs.”

How about the best online pharmacy to obtain Oxiracetam? Although the aforementioned e-pharmacies offer modafinil, they don’t sell Oxiracetam. If you need this nootropic, we recommend you obtain it at Amazon.com, purenootropics.net, or newmind.com.

Dosage of Modafinil vs. Oxiracetam

Because Oxiracetam is unregulated, there are no specified guidelines concerning its dose. Commence at the lowest efficacious dose & work your way up as essential to meet your needs. The advisable Oxiracetam dosage is 750 – 1,500 mg per day. It should be divided into 2 identical doses. Just one Oxiracetam dose in the morning & one in the early afternoon. Taking Oxiracetam at a higher dose has demonstrated no adverse effects. Some individuals may consider taking 1200–2400 mg/day, split into 2 or 3 doses. Since Oxiracetam heightens the efficiency of acetylcholine in the brain, you may consider stacking it with a suitable choline source like CDP Choline or Alpha GPC.

Just like modafinil, if you need optimal cognitive-augmenting effects, Oxiracetam should be administered 1 hour before a planned productivity task or a learning activity. It may also be advantageous to pop Oxiracetam regularly for at least 5 days before the pinnacle in your performance is established.

Take Modafinil

Regarding modafinil dosage, the recommended commencing dose is 200 mg taken once a day (in 24 hours) for treating various sleep disorders discussed in this guide. If using it off-label as needed for productivity & cognitive-ameliorating effects, pop a 200 or 100 mg tab about 40 minutes to an hour before a scheduled task. Peak plasma concentrations of the “smart tab” occur within 2 to 4 hours.

While doses up to 400 mg of the “smart tab” ingested once daily have been well-tolerated, modafinil dosage should be used having consulted with a physician because of the drug’s interaction with certain health conditions & anticipated negative effects [11].

Is There a Difference in Side Effects?

Undoubtedly, Oxiracetam is non-toxic. That means it’s deemed well-tolerated & remarkably safe. Its negative effects are rare but can comprise headaches, nervousness, anxiety, fatigue, insomnia, dizziness, & nausea. These side effects are indeed rare & are generally documented as being mild when experienced. Certain negative effects of Oxiracetam are oftentimes a result of unusually heightened doses of the nootropic. You can easily manage headaches induced by Oxiracetam by mixing it with a good choline supplement. Certainly, headaches are frequently a symptom of a choline deficiency in the brain.

On the other hand, although modafinil is known to be super safe & well-tolerated, it comes with various negative effects. Some are mild, while others are severe, based on the drug response to your health and adherence to medication. Mild negative effects include headache, nausea, dizziness, anxiety, dysgeusia, irritability, fever, vertigo, etc. Moderate side effects can include hypertension, confusion, mania, hallucinations, etc. The “smart tab” severe but very rare negative effects include visual impairment, anaphylactoid reactions, suicidal ideation, Stevens-Johnson syndrome, bronchospasm, etc. [11].

Interaction with Other Meds, Food, and Alcohol

Even though you don’t require a prescription to administer Oxiracetam, it’s indeed strongly advised to check with a physician before taking it. Your physician can inform you about possible med interactions, contemplation for any medical conditions & most importantly, safe methods to use it.

Oxiracetam hasn’t been extensively researched for clinical use, & there is little info obtainable about probable med interactions or contraindications. This nootropic may interact with Carbamazepine (Tegretol), valproic acid, anti-cholinergic & cholinergic meds, warfarin, etc.

Drugs that can interact with modafinil include monoamine oxidase inhibitors, birth control meds, warfarin, as well as CYP2C19 & CYP3A4/5 substrates, among others [11].

Certainly, most foods work well with Oxiracetam & modafinil, but fatty meals delay their onset. Booze, grapefruit, or grapefruit juice can induce some unprecedented negative effects if used with these meds.

Conclusion

That has been a comprehensive discussion of modafinil & Oxiracetam. You’ve seen how these nootropics compare, their benefits, & where to buy them online. Conclusively, we believe modafinil is a single nootropic that offers insanely great benefits, and it’s indeed the safest if taken correctly. Although Oxiracetam is safe, there’s little documented evidence that it is similar to modafinil in its expected effect, although it’s efficacious & rewards with some cognitive benefits. Additionally, it’s non-toxic even administered at high doses, & certainly, it is linked with virtually no serious negative effects. If you need more augmented cognitive benefits, you may consider stacking both nootropics.

References

  1. A Safe Drug to Boost Brainpower. By Melinda Wenner Moyer. Published: March 1, 2016. Scientificamerican.com.
  2. Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review. By R. M. Battleday & A.-K.Brem. Published: November 2015. Sciencedirect.com.
  3. Cyclic GABA-GABOB analogues. IV. Activity on learning and memory. S. Banfi, W. Fonio, E. Allievi, M. Pinza, and L. Dorigotti. Published: 1984. Pubmed.ncbi.nlm.nih.gov.
  4. Oxiracetam increases the release of endogenous glutamate from depolarized rat hippocampal slices. By M. Marchi, E. Besana, and M. Raiteri. Published: August 1990. Pubmed.ncbi.nlm.nih.gov.
  5. [Biochemical studies of oxiracetam (CT-848) on cholinergic neurons]. By D. Mochizuki, S. Sugiyama, Y. Shinoda. Published: January 1992. Pubmed.ncbi.nlm.nih.gov.
  6. Nootropic drugs positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal cultures. By A. Copani, A. A. Genazzani, G. Aleppo, G. Casabona, P. L. Canonico, U. Scapagnini, and F. Nicoletti. Published: April 1992. Pubmed.ncbi.nlm.nih.gov.
  7. Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro. By B. Gabryel, H. I. Trzeciak, A. Pudełko, and P. Cieślik. Published: November 1999. Pubmed.ncbi.nlm.nih.gov.
  8. The GABAB receptor antagonist CGP 36,742 and the nootropic oxiracetam facilitate the formation of long-term memory. By C. Mondadori, H. J. Möbius, and J. Borkowski. Published: May 1996. Pubmed.ncbi.nlm.nih.gov.
  9. The Prohibited List. Retrieved: June 20, 2022. Wada-ama.org.
  10. Neuropsychological Results of Long-Term Therapy with Oxiracetam in Patients with Dementia of Alzheimer Type and Multi-Infarct Dementia in Comparison with a Control Group. By Parnetti L., Mecocci P., Petrini A., Longo A., Buccolieri A., and Senin U. Published: 1989. Karger.com.
  11. Modafinil – Drug Summary. Retrieved: June 20, 2022. Pdr.net.

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